{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Y"],"funding":["the National Key R&amp;D Program of China","the Recruitment Program for Young Professionals of China","other Projects from West China School of Public Health and West China Fourth Hospital, Sichuan University","the National Natural Science Foundation of China","the Promotion Plan for Basic Medical Sciences and the Development Plan for Cutting-Edge Disciplines, Sichuan University"],"pagination":["671"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10537816"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(1)"],"pubmed_abstract":["<h4>Background</h4>This study aims to comprehensively investigate the phenotypic and genetic relationships between four common lipids (high-density lipoprotein cholesterol, HDL-C; low-density lipoprotein cholesterol, LDL-C; total cholesterol, TC; and triglycerides, TG), chronic kidney disease (CKD), and estimated glomerular filtration rate (eGFR).<h4>Methods</h4>We first investigated the observational association of lipids (exposures) with CKD (primary outcome) and eGFR (secondary outcome) using data from UK Biobank. We then explored the genetic relationship using summary statistics from the largest genome-wide association study of four lipids (N = 1,320,016), CKD (N<sub>case</sub> = 41,395, N<sub>control</sub> = 439,303), and eGFR(N = 567,460).<h4>Results</h4>There were significant phenot"],"journal":["Journal of translational medicine"],"pubmed_title":["Understanding the relationship between circulating lipids and risk of chronic kidney disease: a prospective cohort study and large-scale genetic analyses."],"pmcid":["PMC10537816"],"funding_grant_id":["81874283","2022YFC3600600","U22A20359","2022YFC3600604","81673255"],"pubmed_authors":["Li J","Yan P","Chen L","Zhang L","Yang C","Zhao X","Zhang W","Zou Y","Liu Y","Tang M","Liu Z","Yao Y","Jiang X","Cui H","Wang Y","Xiao C","Zhang B","Wu X"],"additional_accession":[]},"is_claimable":false,"name":"Understanding the relationship between circulating lipids and risk of chronic kidney disease: a prospective cohort study and large-scale genetic analyses.","description":"<h4>Background</h4>This study aims to comprehensively investigate the phenotypic and genetic relationships between four common lipids (high-density lipoprotein cholesterol, HDL-C; low-density lipoprotein cholesterol, LDL-C; total cholesterol, TC; and triglycerides, TG), chronic kidney disease (CKD), and estimated glomerular filtration rate (eGFR).<h4>Methods</h4>We first investigated the observational association of lipids (exposures) with CKD (primary outcome) and eGFR (secondary outcome) using data from UK Biobank. We then explored the genetic relationship using summary statistics from the largest genome-wide association study of four lipids (N = 1,320,016), CKD (N<sub>case</sub> = 41,395, N<sub>control</sub> = 439,303), and eGFR(N = 567,460).<h4>Results</h4>There were significant phenot","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2026-04-07T15:38:10.429Z","creation":"2025-02-19T01:20:38.048Z"},"accession":"S-EPMC10537816","cross_references":{"pubmed":["37759214"],"doi":["10.1186/s12967-023-04509-5"]}}