{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2023"],"submitter":["Qi Z"],"pubmed_abstract":["There remains a lack of standard models that have all the characteristics of human diseases. Especially in immunological hepatic fibrosis, the bovine serum albumin (BSA)-induced liver fibrosis models have the same developmental mechanisms as human liver fibrosis models, but have received little attention. We standardized a BSA-induced liver fibrosis model in rats and thoroughly assessed its pathological characteristics. We also used 16S sequencing to assess homeostasis of the intestinal microflora of rats with BSA-induced liver fibrosis and detected various differential metabolites in the serum of these rats using ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). We observed stable and unambiguous histological changes in liver tissue morphology and remarka"],"journal":["Journal of immunology research"],"pagination":["5577850"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10539088"],"repository":["biostudies-literature"],"pubmed_title":["Alterations in the \"Gut-Liver Axis\" on Rats with Immunological Hepatic Fibrosis."],"pmcid":["PMC10539088"],"pubmed_authors":["Liu J","Qi Z","Li D","Qi X","Cong M","Sun H","Liu T","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"Alterations in the \"Gut-Liver Axis\" on Rats with Immunological Hepatic Fibrosis.","description":"There remains a lack of standard models that have all the characteristics of human diseases. Especially in immunological hepatic fibrosis, the bovine serum albumin (BSA)-induced liver fibrosis models have the same developmental mechanisms as human liver fibrosis models, but have received little attention. We standardized a BSA-induced liver fibrosis model in rats and thoroughly assessed its pathological characteristics. We also used 16S sequencing to assess homeostasis of the intestinal microflora of rats with BSA-induced liver fibrosis and detected various differential metabolites in the serum of these rats using ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). We observed stable and unambiguous histological changes in liver tissue morphology and remarka","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-06-04T09:49:29.827Z","creation":"2025-06-01T12:36:58.007Z"},"accession":"S-EPMC10539088","cross_references":{"pubmed":["37781475"],"doi":["10.1155/2023/5577850"]}}