biostudies-literatureUnknown2023Qi ZThere remains a lack of standard models that have all the characteristics of human diseases. Especially in immunological hepatic fibrosis, the bovine serum albumin (BSA)-induced liver fibrosis models have the same developmental mechanisms as human liver fibrosis models, but have received little attention. We standardized a BSA-induced liver fibrosis model in rats and thoroughly assessed its pathological characteristics. We also used 16S sequencing to assess homeostasis of the intestinal microflora of rats with BSA-induced liver fibrosis and detected various differential metabolites in the serum of these rats using ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). We observed stable and unambiguous histological changes in liver tissue morphology and remarkaJournal of immunology research5577850https://www.ebi.ac.uk/biostudies/studies/S-EPMC10539088biostudies-literatureAlterations in the "Gut-Liver Axis" on Rats with Immunological Hepatic Fibrosis.PMC10539088Liu JQi ZLi DQi XCong MSun HLiu TXu YfalseAlterations in the "Gut-Liver Axis" on Rats with Immunological Hepatic Fibrosis.There remains a lack of standard models that have all the characteristics of human diseases. Especially in immunological hepatic fibrosis, the bovine serum albumin (BSA)-induced liver fibrosis models have the same developmental mechanisms as human liver fibrosis models, but have received little attention. We standardized a BSA-induced liver fibrosis model in rats and thoroughly assessed its pathological characteristics. We also used 16S sequencing to assess homeostasis of the intestinal microflora of rats with BSA-induced liver fibrosis and detected various differential metabolites in the serum of these rats using ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). We observed stable and unambiguous histological changes in liver tissue morphology and remarka2023-01-01T00:00:00Z20232026-06-04T09:49:29.827Z2025-06-01T12:36:58.007ZS-EPMC105390883778147510.1155/2023/5577850