{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Grabowska M"],"funding":["Pomeranian Medical University in Szczecin"],"pagination":["1240-1253"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10539461"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["75(5)"],"pubmed_abstract":["<h4>Background</h4>The effect of multidrug immunosuppressive protocols on the salivary glands is still unknown. This study aimed to determine the influence of immunosuppressive regimens based on calcineurin inhibitors (CNIs) and conversion to rapamycin on the morphology, apoptosis, and proliferation of rat salivary glands.<h4>Methods</h4>Male rats received cyclosporin A (CsA), tacrolimus (FK-506), mycophenolate mofetil (MMF), rapamycin (Rapa), and prednisone (Pre) according to three-drug protocols: CMP (CsA, MMF, and Pre), CMP/R (CsA, MMF, and Pre with conversion to Rapa), TMP (FK-506, MMF, and Pre), and TMP/R (FK-506, MMF, and Pre with conversion to Rapa). Morphological and immunohistochemical and quantitative analyses of the salivary glands were performed.<h4>Results</h4>Structural chang"],"journal":["Pharmacological reports : PR"],"pubmed_title":["The long-term effects of multidrug immunosuppressive protocols based on calcineurin inhibitors and conversion to rapamycin on the morphology, apoptosis, and proliferation of rat salivary glands."],"pmcid":["PMC10539461"],"funding_grant_id":["WNoZ-322-01/S/19/2023"],"pubmed_authors":["Teresinski L","Sipak O","Kram A","Grabowska M","Kedzierska-Kapuza K","Piasecka M","Gill K"],"additional_accession":[]},"is_claimable":false,"name":"The long-term effects of multidrug immunosuppressive protocols based on calcineurin inhibitors and conversion to rapamycin on the morphology, apoptosis, and proliferation of rat salivary glands.","description":"<h4>Background</h4>The effect of multidrug immunosuppressive protocols on the salivary glands is still unknown. This study aimed to determine the influence of immunosuppressive regimens based on calcineurin inhibitors (CNIs) and conversion to rapamycin on the morphology, apoptosis, and proliferation of rat salivary glands.<h4>Methods</h4>Male rats received cyclosporin A (CsA), tacrolimus (FK-506), mycophenolate mofetil (MMF), rapamycin (Rapa), and prednisone (Pre) according to three-drug protocols: CMP (CsA, MMF, and Pre), CMP/R (CsA, MMF, and Pre with conversion to Rapa), TMP (FK-506, MMF, and Pre), and TMP/R (FK-506, MMF, and Pre with conversion to Rapa). Morphological and immunohistochemical and quantitative analyses of the salivary glands were performed.<h4>Results</h4>Structural chang","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Oct","modification":"2025-04-22T09:15:48.333Z","creation":"2025-04-05T22:56:24.523Z"},"accession":"S-EPMC10539461","cross_references":{"pubmed":["37658979"],"doi":["10.1007/s43440-023-00521-0"]}}