biostudies-literatureUnknown14YanInflammatory bowel diseases (IBDs) are characterized by chronic relapsing intestinal inflammation that causes digestive system dysfunction. For years, researchers have been working to find more effective and safer therapeutic strategies to treat these diseases. Silibinin (SIL), a flavonoid compound extracted from the seeds of milk thistle plants, possesses multiple biological activities and is traditionally applied to treat liver diseases. SIL is also widely used in the treatment of a variety of inflammatory diseases attributed to its excellent antioxidant and anti-inflammatory effects. However, the efficacy of SIL against IBDs and its mechanisms remain unclear. In this study, using <i>Drosophila melanogaster</i> as a model organism, we found that SIL can effectively relieve intestinal infFrontiers in pharmacology1246960https://www.ebi.ac.uk/biostudies/studies/S-EPMC10539474biostudies-literatureSilibinin alleviates intestinal inflammation via inhibiting JNK signaling in <i>Drosophila</i>.PMC10539474Ren GYanYuan LChen HZhou JYe JZhao XfalseSilibinin alleviates intestinal inflammation via inhibiting JNK signaling in <i>Drosophila</i>.Inflammatory bowel diseases (IBDs) are characterized by chronic relapsing intestinal inflammation that causes digestive system dysfunction. For years, researchers have been working to find more effective and safer therapeutic strategies to treat these diseases. Silibinin (SIL), a flavonoid compound extracted from the seeds of milk thistle plants, possesses multiple biological activities and is traditionally applied to treat liver diseases. SIL is also widely used in the treatment of a variety of inflammatory diseases attributed to its excellent antioxidant and anti-inflammatory effects. However, the efficacy of SIL against IBDs and its mechanisms remain unclear. In this study, using <i>Drosophila melanogaster</i> as a model organism, we found that SIL can effectively relieve intestinal inf2023-01-01T00:00:00Z20232025-04-05T16:02:01.07Z2025-04-05T16:02:01.07ZS-EPMC105394743778170110.3389/fphar.2023.1246960