{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(39)"],"submitter":["Gan-Or B"],"pubmed_abstract":["Vocalizations provide a means of communication with high fidelity and information rate for many species. Diencephalon and brainstem neural circuits have been shown to control mouse vocal production; however, the role of cortical circuits in this process is debatable. Using electrical and optogenetic stimulation, we identified a cortical region in the anterior cingulate cortex in which stimulation elicits ultrasonic vocalizations. Moreover, fiber photometry showed an increase in Ca<sup>2+</sup> dynamics preceding vocal initiation, whereas optogenetic suppression in this cortical area caused mice to emit fewer vocalizations. Last, electrophysiological recordings indicated a differential increase in neural activity in response to female social exposure dependent on vocal output. Together, these results indicate that the cortex is a key node in the neuronal circuits controlling vocal behavior in mice."],"journal":["Science advances"],"pagination":["eade6992"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10541007"],"repository":["biostudies-literature"],"pubmed_title":["Cortical circuits modulate mouse social vocalizations."],"pmcid":["PMC10541007"],"pubmed_authors":["London M","Gan-Or B"],"additional_accession":[]},"is_claimable":false,"name":"Cortical circuits modulate mouse social vocalizations.","description":"Vocalizations provide a means of communication with high fidelity and information rate for many species. Diencephalon and brainstem neural circuits have been shown to control mouse vocal production; however, the role of cortical circuits in this process is debatable. Using electrical and optogenetic stimulation, we identified a cortical region in the anterior cingulate cortex in which stimulation elicits ultrasonic vocalizations. Moreover, fiber photometry showed an increase in Ca<sup>2+</sup> dynamics preceding vocal initiation, whereas optogenetic suppression in this cortical area caused mice to emit fewer vocalizations. Last, electrophysiological recordings indicated a differential increase in neural activity in response to female social exposure dependent on vocal output. Together, these results indicate that the cortex is a key node in the neuronal circuits controlling vocal behavior in mice.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2025-04-22T09:15:15.281Z","creation":"2025-04-05T22:59:40.295Z"},"accession":"S-EPMC10541007","cross_references":{"pubmed":["37774030"],"doi":["10.1126/sciadv.ade6992"]}}