{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(16)"],"submitter":["Huang Y"],"pubmed_abstract":["Autophagy is a promising target for promoting neural regeneration, which is essential for sensorimotor recovery following traumatic brain injury (TBI). Whether neuronal heat shock protein B2 (HSPB2), a small molecular heat shock protein, reduces injury and promotes recovery following TBI remains unclear. In this study, we demonstrated that HSPB2 was significantly increased in the neurons of a TBI mouse model, patients, and primary neuron cultures subjected to oxygen/glucose deprivation and reperfusion treatment. Upon creating a tamoxifen-induced neuron-specific HSPB2 overexpression transgenic mouse model, we found that elevated HSPB2 levels promoted long-term sensorimotor recovery and alleviated tissue loss after TBI. We also demonstrated that HSPB2 enhanced white matter structural and fun"],"journal":["JCI insight"],"pagination":["e168919"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10543718"],"repository":["biostudies-literature"],"pubmed_title":["HSPB2 facilitates neural regeneration through autophagy for sensorimotor recovery after traumatic brain injury."],"pmcid":["PMC10543718"],"pubmed_authors":["Meng S","Li J","Lyu Y","Xiang J","Wu B","Shi Z","Wu G","Xu ZX","Huang Y","Hu J","Gao Y","Jia X","Wang Y","Shi H"],"additional_accession":[]},"is_claimable":false,"name":"HSPB2 facilitates neural regeneration through autophagy for sensorimotor recovery after traumatic brain injury.","description":"Autophagy is a promising target for promoting neural regeneration, which is essential for sensorimotor recovery following traumatic brain injury (TBI). Whether neuronal heat shock protein B2 (HSPB2), a small molecular heat shock protein, reduces injury and promotes recovery following TBI remains unclear. In this study, we demonstrated that HSPB2 was significantly increased in the neurons of a TBI mouse model, patients, and primary neuron cultures subjected to oxygen/glucose deprivation and reperfusion treatment. Upon creating a tamoxifen-induced neuron-specific HSPB2 overexpression transgenic mouse model, we found that elevated HSPB2 levels promoted long-term sensorimotor recovery and alleviated tissue loss after TBI. We also demonstrated that HSPB2 enhanced white matter structural and fun","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2025-04-22T16:03:13.077Z","creation":"2025-04-06T01:33:53.546Z"},"accession":"S-EPMC10543718","cross_references":{"pubmed":["37606039"],"doi":["10.1172/jci.insight.168919"]}}