biostudies-literatureUnknown8(16)Huang YAutophagy is a promising target for promoting neural regeneration, which is essential for sensorimotor recovery following traumatic brain injury (TBI). Whether neuronal heat shock protein B2 (HSPB2), a small molecular heat shock protein, reduces injury and promotes recovery following TBI remains unclear. In this study, we demonstrated that HSPB2 was significantly increased in the neurons of a TBI mouse model, patients, and primary neuron cultures subjected to oxygen/glucose deprivation and reperfusion treatment. Upon creating a tamoxifen-induced neuron-specific HSPB2 overexpression transgenic mouse model, we found that elevated HSPB2 levels promoted long-term sensorimotor recovery and alleviated tissue loss after TBI. We also demonstrated that HSPB2 enhanced white matter structural and funJCI insighte168919https://www.ebi.ac.uk/biostudies/studies/S-EPMC10543718biostudies-literatureHSPB2 facilitates neural regeneration through autophagy for sensorimotor recovery after traumatic brain injury.PMC10543718Meng SLi JLyu YXiang JWu BShi ZWu GXu ZXHuang YHu JGao YJia XWang YShi HfalseHSPB2 facilitates neural regeneration through autophagy for sensorimotor recovery after traumatic brain injury.Autophagy is a promising target for promoting neural regeneration, which is essential for sensorimotor recovery following traumatic brain injury (TBI). Whether neuronal heat shock protein B2 (HSPB2), a small molecular heat shock protein, reduces injury and promotes recovery following TBI remains unclear. In this study, we demonstrated that HSPB2 was significantly increased in the neurons of a TBI mouse model, patients, and primary neuron cultures subjected to oxygen/glucose deprivation and reperfusion treatment. Upon creating a tamoxifen-induced neuron-specific HSPB2 overexpression transgenic mouse model, we found that elevated HSPB2 levels promoted long-term sensorimotor recovery and alleviated tissue loss after TBI. We also demonstrated that HSPB2 enhanced white matter structural and fun2023-01-01T00:00:00Z2023 Aug2025-04-22T16:03:13.077Z2025-04-06T01:33:53.546ZS-EPMC105437183760603910.1172/jci.insight.168919