{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wood ME"],"funding":["NIA NIH HHS","NINDS NIH HHS","Canadian Institutes of Health Research"],"pagination":["4651-4661"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10544702"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(10)"],"pubmed_abstract":["<h4>Introduction</h4>We examined whether sex modifies the association between APOE ε2 and cognitive decline in two independent samples.<h4>Methods</h4>We used observational data from cognitively unimpaired non-Hispanic White (NHW) and non-Hispanic Black (NHB) adults. Linear mixed models examined interactive associations of APOE genotype (ε2 or ε4 carrier vs. ε3/ε3) and sex on cognitive decline in NHW and NHB participants separately.<h4>Results</h4>In both Sample 1 (N = 9766) and Sample 2 (N = 915), sex modified the association between APOE ε2 and cognitive decline in NHW participants. Specifically, relative to APOE ε3/ε3, APOE ε2 protected against cognitive decline in men but not women. Among APOE ε2 carriers, men had slower decline than women. Among APOE ε3/ε3 carriers, cognitive trajecto"],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["Sex differences in associations between APOE ε2 and longitudinal cognitive decline."],"pmcid":["PMC10544702"],"funding_grant_id":["P30 AG053760","P50 AG005146","P50 AG005142","R01 AG072475","P50 AG047266","P20 AG068053","UF1 NS125513","T32 AG000247","P30 AG019610","R01 AG022018","K99 AG061238","R00 AG061238","P30 AG072958","P30 AG072959","P50 AG008702","P30 AG010124","P30 AG012300","P50 AG047270","P30 AG066546","P30 AG010161","P30 AG066509","P30 AG049638","U24 AG072122","P20 AG068024","P30 AG072947","R01 AG015819","P30 AG028383","P30 AG013846","K99 AG065501","P30 AG008017","P30 AG010133","P50 AG033514","P50 AG005681","R01 AG052488","RF1 AG070436","P50 AG047366","P30 AG072975","P20 AG068077","R01 AG071638","P50 AG023501","P30 AG008051","P30 AG010129","P30 AG013854","173253","P50 AG005138","R01 AG059727","P50 AG005134","P50 AG005136","P50 AG025688","P30 AG035982","P50 AG005131","RF1 AG054617","R01 NS017950","P50 AG005133","P50 AG016574","P20 AG068082","P50 AG016573","R01 AG017917","438475"],"pubmed_authors":["Casaletto KB","Rabin JS","Barnes LL","George KM","Swardfager W","Joie R","Brickman AM","ADNI and Prevent-AD Research Groups","Wong YY","Xiong LY","Black SE","Binet AP","Masellis M","Satizabal CL","Dams-O'Connor K","Schneider JA","Villeneuve S","Buckley RF","Palta P","Wood ME","Lim ASP","Kumar RG","Nichols E","Pa J"],"additional_accession":[]},"is_claimable":false,"name":"Sex differences in associations between APOE ε2 and longitudinal cognitive decline.","description":"<h4>Introduction</h4>We examined whether sex modifies the association between APOE ε2 and cognitive decline in two independent samples.<h4>Methods</h4>We used observational data from cognitively unimpaired non-Hispanic White (NHW) and non-Hispanic Black (NHB) adults. Linear mixed models examined interactive associations of APOE genotype (ε2 or ε4 carrier vs. ε3/ε3) and sex on cognitive decline in NHW and NHB participants separately.<h4>Results</h4>In both Sample 1 (N = 9766) and Sample 2 (N = 915), sex modified the association between APOE ε2 and cognitive decline in NHW participants. Specifically, relative to APOE ε3/ε3, APOE ε2 protected against cognitive decline in men but not women. Among APOE ε2 carriers, men had slower decline than women. Among APOE ε3/ε3 carriers, cognitive trajecto","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Oct","modification":"2025-04-04T11:36:37.371Z","creation":"2025-04-04T11:36:37.371Z"},"accession":"S-EPMC10544702","cross_references":{"pubmed":["36994910"],"doi":["10.1002/alz.13036"]}}