{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(10)"],"submitter":["Liu W"],"pubmed_abstract":["<h4>Background</h4>This study aimed to identify the key genes involved in the development of multiple primary lung cancers.<h4>Methods</h4>Differential expression analysis was performed, followed by comparing the infiltration levels of 22 immune cell types between multiple and single primary lung adenocarcinomas. Marker genes for epithelial cells with different proportions between the two types of lung adenocarcinomas were identified. The common genes between the marker genes and differentially expressed genes were identified. Finally, the effects of the key genes were tested on the in vitro proliferation, migration and morphology.<h4>Results</h4>The infiltration levels of helper follicular T cells, resting NK cells, activated NK cells, M2 macrophages and resting mast cells were higher in "],"journal":["Clinical and translational medicine"],"pagination":["e1368"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10545892"],"repository":["biostudies-literature"],"pubmed_title":["Macrophage migration inhibitory factor may contribute to the occurrence of multiple primary lung adenocarcinomas."],"pmcid":["PMC10545892"],"pubmed_authors":["Yang HS","Zhu Y","Zhi FH","Feng YF","Luo HH","Liu W","Lei YY"],"additional_accession":[]},"is_claimable":false,"name":"Macrophage migration inhibitory factor may contribute to the occurrence of multiple primary lung adenocarcinomas.","description":"<h4>Background</h4>This study aimed to identify the key genes involved in the development of multiple primary lung cancers.<h4>Methods</h4>Differential expression analysis was performed, followed by comparing the infiltration levels of 22 immune cell types between multiple and single primary lung adenocarcinomas. Marker genes for epithelial cells with different proportions between the two types of lung adenocarcinomas were identified. The common genes between the marker genes and differentially expressed genes were identified. Finally, the effects of the key genes were tested on the in vitro proliferation, migration and morphology.<h4>Results</h4>The infiltration levels of helper follicular T cells, resting NK cells, activated NK cells, M2 macrophages and resting mast cells were higher in ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Oct","modification":"2026-05-28T18:23:32.463Z","creation":"2025-02-19T00:00:53.174Z"},"accession":"S-EPMC10545892","cross_references":{"pubmed":["37784249"],"doi":["10.1002/ctm2.1368"]}}