{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hsia K"],"funding":["NCATS NIH HHS","Tufts University School of Medicine","NIDDK NIH HHS","National Institutes of Health"],"pagination":["1613-1621"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10547232"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(10)"],"pubmed_abstract":["<h4>Background</h4>Although gut fungi have been implicated in the immunopathogenesis of inflammatory bowel disease, the fungal microbiome has not been deeply explored across endohistologic activity and treatment exposure in ulcerative colitis.<h4>Methods</h4>We analyzed data from the SPARC IBD (Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease) registry. We evaluated the fungal composition of fecal samples from 98 patients with ulcerative colitis across endoscopic activity (n = 43), endohistologic activity (n = 41), and biologic exposure (n = 82). Across all subgroups, we assessed fungal diversity and differential abundance of taxonomic groups.<h4>Results</h4>We identified 500 unique fungal amplicon sequence variants across the cohort of 82 patients, dominated by"],"journal":["Inflammatory bowel diseases"],"pubmed_title":["Alterations in the Fungal Microbiome in Ulcerative Colitis."],"pmcid":["PMC10547232"],"funding_grant_id":["KL2TR002545","R01 DK135937","KL2 TR002545"],"pubmed_authors":["Zhao N","Algarrahi K","Michaud DS","Chung M","Montaser Kouhsari L","Chen H","Hsia K","Singh S","Fu M","Jangi S"],"additional_accession":[]},"is_claimable":false,"name":"Alterations in the Fungal Microbiome in Ulcerative Colitis.","description":"<h4>Background</h4>Although gut fungi have been implicated in the immunopathogenesis of inflammatory bowel disease, the fungal microbiome has not been deeply explored across endohistologic activity and treatment exposure in ulcerative colitis.<h4>Methods</h4>We analyzed data from the SPARC IBD (Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease) registry. We evaluated the fungal composition of fecal samples from 98 patients with ulcerative colitis across endoscopic activity (n = 43), endohistologic activity (n = 41), and biologic exposure (n = 82). Across all subgroups, we assessed fungal diversity and differential abundance of taxonomic groups.<h4>Results</h4>We identified 500 unique fungal amplicon sequence variants across the cohort of 82 patients, dominated by","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Oct","modification":"2026-06-02T08:33:00.801Z","creation":"2026-04-16T03:11:35.481Z"},"accession":"S-EPMC10547232","cross_references":{"pubmed":["37221272"],"doi":["10.1093/ibd/izad082"]}}