biostudies-literatureHsia KNCATS NIH HHSTufts University School of MedicineNIDDK NIH HHSNational Institutes of Health1613-1621https://www.ebi.ac.uk/biostudies/studies/S-EPMC10547232biostudies-literatureUnknown29(10)<h4>Background</h4>Although gut fungi have been implicated in the immunopathogenesis of inflammatory bowel disease, the fungal microbiome has not been deeply explored across endohistologic activity and treatment exposure in ulcerative colitis.<h4>Methods</h4>We analyzed data from the SPARC IBD (Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease) registry. We evaluated the fungal composition of fecal samples from 98 patients with ulcerative colitis across endoscopic activity (n = 43), endohistologic activity (n = 41), and biologic exposure (n = 82). Across all subgroups, we assessed fungal diversity and differential abundance of taxonomic groups.<h4>Results</h4>We identified 500 unique fungal amplicon sequence variants across the cohort of 82 patients, dominated byInflammatory bowel diseasesAlterations in the Fungal Microbiome in Ulcerative Colitis.PMC10547232KL2TR002545R01 DK135937KL2 TR002545Zhao NAlgarrahi KMichaud DSChung MMontaser Kouhsari LChen HHsia KSingh SFu MJangi SfalseAlterations in the Fungal Microbiome in Ulcerative Colitis.<h4>Background</h4>Although gut fungi have been implicated in the immunopathogenesis of inflammatory bowel disease, the fungal microbiome has not been deeply explored across endohistologic activity and treatment exposure in ulcerative colitis.<h4>Methods</h4>We analyzed data from the SPARC IBD (Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease) registry. We evaluated the fungal composition of fecal samples from 98 patients with ulcerative colitis across endoscopic activity (n = 43), endohistologic activity (n = 41), and biologic exposure (n = 82). Across all subgroups, we assessed fungal diversity and differential abundance of taxonomic groups.<h4>Results</h4>We identified 500 unique fungal amplicon sequence variants across the cohort of 82 patients, dominated by2023-01-01T00:00:00Z2023 Oct2026-06-02T08:33:00.801Z2026-04-16T03:11:35.481ZS-EPMC105472323722127210.1093/ibd/izad082