biostudies-literatureHsu CCTaipei Veterans General HospitalNational Science and Technology Council518-528https://www.ebi.ac.uk/biostudies/studies/S-EPMC10550875biostudies-literatureUnknown56(4)<h4>Background</h4>The effectiveness and safety of direct oral anticoagulants (DOACs) in patients with atrial fibrillation (AF) and advanced kidney disease (AKD) has not been fully established.<h4>Objectives</h4>To determine the effectiveness and safety related to pooled or specific DOACs to that with warfarin in patients with AF and AKD.<h4>Methods</h4>Patients with AF and AKD (estimated glomerular filtration rate < 30 mL/min) who received DOAC or warfarin from July 2011 to December 2020 were retrospectively identified in a medical center in Taiwan. Primary outcomes were hospitalized for stroke/systemic embolism and major bleeding. Secondary outcomes included any ischemia and any bleeding.<h4>Results</h4>A total of 1,011 patients were recruited, of whom 809 (80.0%) were in the DOACs groupJournal of thrombosis and thrombolysisEffectiveness and safety of direct oral anticoagulants versus warfarin in patients with atrial fibrillation and advanced kidney disease.PMC10550875V111B-043, V111EA-017MOST111-2635-B-075-001Chou CYHsu CCWang SFChen KHChang YLChen CCChang SLfalseEffectiveness and safety of direct oral anticoagulants versus warfarin in patients with atrial fibrillation and advanced kidney disease.<h4>Background</h4>The effectiveness and safety of direct oral anticoagulants (DOACs) in patients with atrial fibrillation (AF) and advanced kidney disease (AKD) has not been fully established.<h4>Objectives</h4>To determine the effectiveness and safety related to pooled or specific DOACs to that with warfarin in patients with AF and AKD.<h4>Methods</h4>Patients with AF and AKD (estimated glomerular filtration rate < 30 mL/min) who received DOAC or warfarin from July 2011 to December 2020 were retrospectively identified in a medical center in Taiwan. Primary outcomes were hospitalized for stroke/systemic embolism and major bleeding. Secondary outcomes included any ischemia and any bleeding.<h4>Results</h4>A total of 1,011 patients were recruited, of whom 809 (80.0%) were in the DOACs group2023-01-01T00:00:00Z2023 Nov2026-06-02T19:02:37.199Z2025-04-19T07:15:25.016ZS-EPMC105508753745290610.1007/s11239-023-02859-x