{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["37(13)"],"submitter":["van Pul L"],"pubmed_abstract":["<h4>Objectives</h4>Core fucosylation by fucosyltransferase 8 (FUT8) is an important posttranslational modification that impacts components of the immune system. Genetic variations in FUT8 can alter its function and could, therefore, play a role in the antiviral immune response and pathogenesis of HIV-1. This study analysed the effect of a single nucleotide polymorphism (SNP) in FUT8 on the clinical course of HIV-1 infection.<h4>Design/methods</h4>The effect of SNPs in FUT8 on untreated HIV-1 disease outcome were analysed in a cohort of 304 people with HIV-1 (PWH) using survival analysis. Flow-cytometry was used to determine the effect of SNP on T-cell activation, differentiation and exhaustion/senescence. T-cell function was determined by proliferation assay and by measuring intracellular "],"journal":["AIDS (London, England)"],"pagination":["1959-1969"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10552802"],"repository":["biostudies-literature"],"pubmed_title":["A genetic variation in fucosyltransferase 8 accelerates HIV-1 disease progression indicating a role for N-glycan fucosylation."],"pmcid":["PMC10552802"],"pubmed_authors":["Maurer I","Harskamp AM","van Dort KA","Kootstra NA","van Pul L","Boeser-Nunnink BDM"],"additional_accession":[]},"is_claimable":false,"name":"A genetic variation in fucosyltransferase 8 accelerates HIV-1 disease progression indicating a role for N-glycan fucosylation.","description":"<h4>Objectives</h4>Core fucosylation by fucosyltransferase 8 (FUT8) is an important posttranslational modification that impacts components of the immune system. Genetic variations in FUT8 can alter its function and could, therefore, play a role in the antiviral immune response and pathogenesis of HIV-1. This study analysed the effect of a single nucleotide polymorphism (SNP) in FUT8 on the clinical course of HIV-1 infection.<h4>Design/methods</h4>The effect of SNPs in FUT8 on untreated HIV-1 disease outcome were analysed in a cohort of 304 people with HIV-1 (PWH) using survival analysis. Flow-cytometry was used to determine the effect of SNP on T-cell activation, differentiation and exhaustion/senescence. T-cell function was determined by proliferation assay and by measuring intracellular ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2026-05-28T11:09:22.213Z","creation":"2025-04-04T12:48:48.496Z"},"accession":"S-EPMC10552802","cross_references":{"pubmed":["37598360"],"doi":["10.1097/QAD.0000000000003689"]}}