{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Dormegny-Jeanjean LC"],"pubmed_abstract":["Introduction
Among treatment-resistant depression (TRD), we identified anergic-anhedonic clinical presentations (TRAD) as putatively responsive to pro-dopaminergic strategies. Based on the literature, non-selective monoamine oxidase inhibitors (MAOI) and dopamine D2 receptor agonists (D2RAG) were sequentially introduced, frequently under the coverage of a mood stabilizer. This two-step therapeutic strategy will be referred to as the Dopaminergic Antidepressant Therapy Algorithm (DATA). We describe the short and long-term outcomes of TRAD managed according to DATA guidelines.Method
Out of 52 outpatients with TRAD treated with DATA in a single expert center, 48 were included in the analysis [severity - QIDS (Quick Inventory of Depressive Symptomatology) = 16 ± 3; episode dura"],"journal":["Frontiers in psychiatry"],"pagination":["1194090"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10565009"],"repository":["biostudies-literature"],"pubmed_title":["Potential efficacy of dopaminergic antidepressants in treatment resistant anergic-anhedonic depression results of the chronic anergic-anhedonic depression open trial - CADOT."],"pmcid":["PMC10565009"],"pubmed_authors":["Meyer C","Dormegny-Jeanjean LC","Humbert I","Blanc F","Mainberger O","Meyer G","Bertschy G","Foucher JR","Berna F","Tomsa M","Landre L","Javelot H","Schorr B","de Billy C","Danila V","Causin JB","Pfleger G","Weibel S","Obrecht A"],"additional_accession":[]},"is_claimable":false,"name":"Potential efficacy of dopaminergic antidepressants in treatment resistant anergic-anhedonic depression results of the chronic anergic-anhedonic depression open trial - CADOT.","description":"Introduction
Among treatment-resistant depression (TRD), we identified anergic-anhedonic clinical presentations (TRAD) as putatively responsive to pro-dopaminergic strategies. Based on the literature, non-selective monoamine oxidase inhibitors (MAOI) and dopamine D2 receptor agonists (D2RAG) were sequentially introduced, frequently under the coverage of a mood stabilizer. This two-step therapeutic strategy will be referred to as the Dopaminergic Antidepressant Therapy Algorithm (DATA). We describe the short and long-term outcomes of TRAD managed according to DATA guidelines.Method
Out of 52 outpatients with TRAD treated with DATA in a single expert center, 48 were included in the analysis [severity - QIDS (Quick Inventory of Depressive Symptomatology) = 16 ± 3; episode dura","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-18T16:46:09.694Z","creation":"2025-04-07T04:08:45.265Z"},"accession":"S-EPMC10565009","cross_references":{"pubmed":["37829759"],"doi":["10.3389/fpsyt.2023.1194090"]}}