biostudies-literatureUnknown14Dormegny-Jeanjean LC<h4>Introduction</h4>Among treatment-resistant depression (TRD), we identified anergic-anhedonic clinical presentations (TRAD) as putatively responsive to pro-dopaminergic strategies. Based on the literature, non-selective monoamine oxidase inhibitors (MAOI) and dopamine D2 receptor agonists (D2RAG) were sequentially introduced, frequently under the coverage of a mood stabilizer. This two-step therapeutic strategy will be referred to as the Dopaminergic Antidepressant Therapy Algorithm (DATA). We describe the short and long-term outcomes of TRAD managed according to DATA guidelines.<h4>Method</h4>Out of 52 outpatients with TRAD treated with DATA in a single expert center, 48 were included in the analysis [severity - QIDS (Quick Inventory of Depressive Symptomatology) = 16 ± 3; episode duraFrontiers in psychiatry1194090https://www.ebi.ac.uk/biostudies/studies/S-EPMC10565009biostudies-literaturePotential efficacy of dopaminergic antidepressants in treatment resistant anergic-anhedonic depression results of the chronic anergic-anhedonic depression open trial - CADOT.PMC10565009Meyer CDormegny-Jeanjean LCHumbert IBlanc FMainberger OMeyer GBertschy GFoucher JRBerna FTomsa MLandre LJavelot HSchorr Bde Billy CDanila VCausin JBPfleger GWeibel SObrecht AfalsePotential efficacy of dopaminergic antidepressants in treatment resistant anergic-anhedonic depression results of the chronic anergic-anhedonic depression open trial - CADOT.<h4>Introduction</h4>Among treatment-resistant depression (TRD), we identified anergic-anhedonic clinical presentations (TRAD) as putatively responsive to pro-dopaminergic strategies. Based on the literature, non-selective monoamine oxidase inhibitors (MAOI) and dopamine D2 receptor agonists (D2RAG) were sequentially introduced, frequently under the coverage of a mood stabilizer. This two-step therapeutic strategy will be referred to as the Dopaminergic Antidepressant Therapy Algorithm (DATA). We describe the short and long-term outcomes of TRAD managed according to DATA guidelines.<h4>Method</h4>Out of 52 outpatients with TRAD treated with DATA in a single expert center, 48 were included in the analysis [severity - QIDS (Quick Inventory of Depressive Symptomatology) = 16 ± 3; episode dura2023-01-01T00:00:00Z20232025-04-18T16:46:09.694Z2025-04-07T04:08:45.265ZS-EPMC105650093782975910.3389/fpsyt.2023.1194090