{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["481(11)"],"submitter":["Dean DC"],"pubmed_abstract":["<h4>Background</h4>Liposarcoma is the most commonly diagnosed subtype of soft tissue sarcoma. As these tumors often arise near vital organs and neurovascular structures, complete resection can be challenging; consequently, recurrence rates are high. Additionally, available chemotherapeutic agents have shown limited benefit and substantial toxicities. There is, therefore, a clear and unmet need for novel therapeutics for liposarcoma. Discoidin domain receptor tyrosine kinase 1 (DDR1) is involved in adhesion, proliferation, differentiation, migration, and metastasis in several cancers. However, the expression and clinical importance of DDR1 in liposarcoma are unknown.<h4>Questions/purposes</h4>The purposes of this study were to assess (1) the expression, (2) the association between DDR1 and "],"journal":["Clinical orthopaedics and related research"],"pagination":["2140-2153"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10567009"],"repository":["biostudies-literature"],"pubmed_title":["Discoidin Domain Receptor Tyrosine Kinase 1 (DDR1) Is a Novel Therapeutic Target in Liposarcoma: A Tissue Microarray Study."],"pmcid":["PMC10567009"],"pubmed_authors":["Duan Z","Hornicek FJ","Feng W","Trent JC","Walker RL","Dean DC","Rosenberg AE","Thanindratarn P","Temple HT"],"additional_accession":[]},"is_claimable":false,"name":"Discoidin Domain Receptor Tyrosine Kinase 1 (DDR1) Is a Novel Therapeutic Target in Liposarcoma: A Tissue Microarray Study.","description":"<h4>Background</h4>Liposarcoma is the most commonly diagnosed subtype of soft tissue sarcoma. As these tumors often arise near vital organs and neurovascular structures, complete resection can be challenging; consequently, recurrence rates are high. Additionally, available chemotherapeutic agents have shown limited benefit and substantial toxicities. There is, therefore, a clear and unmet need for novel therapeutics for liposarcoma. Discoidin domain receptor tyrosine kinase 1 (DDR1) is involved in adhesion, proliferation, differentiation, migration, and metastasis in several cancers. However, the expression and clinical importance of DDR1 in liposarcoma are unknown.<h4>Questions/purposes</h4>The purposes of this study were to assess (1) the expression, (2) the association between DDR1 and ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-04-04T03:01:34.313Z","creation":"2025-04-04T03:01:34.313Z"},"accession":"S-EPMC10567009","cross_references":{"pubmed":["37768856"],"doi":["10.1097/CORR.0000000000002865","10.1097/corr.0000000000002865"]}}