biostudies-literatureUnknown481(11)Dean DC<h4>Background</h4>Liposarcoma is the most commonly diagnosed subtype of soft tissue sarcoma. As these tumors often arise near vital organs and neurovascular structures, complete resection can be challenging; consequently, recurrence rates are high. Additionally, available chemotherapeutic agents have shown limited benefit and substantial toxicities. There is, therefore, a clear and unmet need for novel therapeutics for liposarcoma. Discoidin domain receptor tyrosine kinase 1 (DDR1) is involved in adhesion, proliferation, differentiation, migration, and metastasis in several cancers. However, the expression and clinical importance of DDR1 in liposarcoma are unknown.<h4>Questions/purposes</h4>The purposes of this study were to assess (1) the expression, (2) the association between DDR1 and Clinical orthopaedics and related research2140-2153https://www.ebi.ac.uk/biostudies/studies/S-EPMC10567009biostudies-literatureDiscoidin Domain Receptor Tyrosine Kinase 1 (DDR1) Is a Novel Therapeutic Target in Liposarcoma: A Tissue Microarray Study.PMC10567009Duan ZHornicek FJFeng WTrent JCWalker RLDean DCRosenberg AEThanindratarn PTemple HTfalseDiscoidin Domain Receptor Tyrosine Kinase 1 (DDR1) Is a Novel Therapeutic Target in Liposarcoma: A Tissue Microarray Study.<h4>Background</h4>Liposarcoma is the most commonly diagnosed subtype of soft tissue sarcoma. As these tumors often arise near vital organs and neurovascular structures, complete resection can be challenging; consequently, recurrence rates are high. Additionally, available chemotherapeutic agents have shown limited benefit and substantial toxicities. There is, therefore, a clear and unmet need for novel therapeutics for liposarcoma. Discoidin domain receptor tyrosine kinase 1 (DDR1) is involved in adhesion, proliferation, differentiation, migration, and metastasis in several cancers. However, the expression and clinical importance of DDR1 in liposarcoma are unknown.<h4>Questions/purposes</h4>The purposes of this study were to assess (1) the expression, (2) the association between DDR1 and 2023-01-01T00:00:00Z2023 Nov2025-04-04T03:01:34.313Z2025-04-04T03:01:34.313ZS-EPMC105670093776885610.1097/CORR.000000000000286510.1097/corr.0000000000002865