{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ma X"],"funding":["NIEHS NIH HHS","NCI NIH HHS"],"pagination":["100017"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10568217"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["1(2)"],"pubmed_abstract":["The use of nanoparticles in agrichemical formula and food products as additives has increased their chances of accumulation in humans via oral intake. Due to their potential toxicity, it is critical to understand their fate and distribution following oral intake. Cerium oxide nanoparticle (CeO<sub>2</sub>NP) is commonly used in agriculture and is highly stable in the environment. As such, it has been used as a model chemical to investigate nanoparticle's distribution and clearance. Based on their estimated human exposure levels, 0.15-0.75 mg/kg body weight/day of CeO<sub>2</sub>NPs with different sizes and surface charges (30-50 nm with negative charge and <25 nm with positive charge) were gavaged into C57BL/6 female mice daily. After 10-d, 50% of mice in each treatment were terminated, wi"],"journal":["Soil & Environmental Health"],"pubmed_title":["Fate and distribution of orally-ingested CeO<sub>2</sub>-nanoparticles based on a mouse model: Implication for human health."],"pmcid":["PMC10568217"],"funding_grant_id":["P30 ES029067","R35 CA197707"],"pubmed_authors":["Xu L","Yang H","Sharma VK","Chapkin RS","Ma X","Landrock KK","Wang X","Shi H"],"additional_accession":[]},"is_claimable":false,"name":"Fate and distribution of orally-ingested CeO<sub>2</sub>-nanoparticles based on a mouse model: Implication for human health.","description":"The use of nanoparticles in agrichemical formula and food products as additives has increased their chances of accumulation in humans via oral intake. Due to their potential toxicity, it is critical to understand their fate and distribution following oral intake. Cerium oxide nanoparticle (CeO<sub>2</sub>NP) is commonly used in agriculture and is highly stable in the environment. As such, it has been used as a model chemical to investigate nanoparticle's distribution and clearance. Based on their estimated human exposure levels, 0.15-0.75 mg/kg body weight/day of CeO<sub>2</sub>NPs with different sizes and surface charges (30-50 nm with negative charge and <25 nm with positive charge) were gavaged into C57BL/6 female mice daily. After 10-d, 50% of mice in each treatment were terminated, wi","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-05-29T19:26:03.24Z","creation":"2024-11-06T01:30:52.177Z"},"accession":"S-EPMC10568217","cross_references":{"pubmed":["37830053"],"doi":["10.1016/j.seh.2023.100017"]}}