{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["ENIGMA Clinical High Risk for Psychosis Working Group"],"funding":["NCATS NIH HHS","NIBIB NIH HHS","NIMH NIH HHS","Medical Research Council","National Institute for Health Research (NIHR)","Lundbeck Foundation"],"pagination":["77-88"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10568447"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["81(1)"],"pubmed_abstract":["<h4>Importance</h4>The lack of robust neuroanatomical markers of psychosis risk has been traditionally attributed to heterogeneity. A complementary hypothesis is that variation in neuroanatomical measures in individuals at psychosis risk may be nested within the range observed in healthy individuals.<h4>Objective</h4>To quantify deviations from the normative range of neuroanatomical variation in individuals at clinical high risk for psychosis (CHR-P) and evaluate their overlap with healthy variation and their association with positive symptoms, cognition, and conversion to a psychotic disorder.<h4>Design, setting, and participants</h4>This case-control study used clinical-, IQ-, and neuroimaging software (FreeSurfer)-derived regional measures of cortical thickness (CT), cortical surface ar"],"journal":["JAMA psychiatry"],"pubmed_title":["Normative Modeling of Brain Morphometry in Clinical High Risk for Psychosis."],"pmcid":["PMC10568447"],"funding_grant_id":["R01 MH113564","R01 MH113533","UL1 TR004419","R01 MH115031","NIHR-INF-0779","R287-2018-1485","T32 MH015144","U54 EB020403","R01 MH115332","R01 MH116147","R01 MH129636","R01 MH123163","T32 MH122394","K23 MH085063","R01 MH076989","R21 MH117434","MR/L011689/1","R01 MH105246","K01 MH112774","R01 MH100043"],"pubmed_authors":["Ebdrup BH","Kahn RS","Sorensen ME","Kaess M","Mathalon DH","Pariente JC","Jalbrzikowski M","Rasser PE","Hegelstad WTV","Schiffman J","Wenneberg C","Bachman P","Koike S","Waltz JA","Leon-Ortiz P","Yuan L","van Amelsvoort TAMJ","Westlye LT","Lin A","He Y","Mora-Duran R","Baldwin H","Pantelis C","Velakoulis D","Raghava JM","Hamilton HK","Cropley VL","Haas SS","Lee J","Sasabayashi D","Kim M","Kristensen TD","Resch F","Tang J","Værnes TG","Hooker CI","Yamasue H","Vinogradov S","Lemmers-Jansen ILJ","Amminger GP","Hernaus D","Agartz I","Nordholm D","Wood SJ","Cooper RE","Rossberg JI","Tomyshev AS","Allen P","van Erp TGM","Klaunig MJ","Reyes-Madrigal F","Lawrie SM","Ouyang L","de Haan L","de la Fuente-Sandoval C","Heekeren K","Nordentoft M","Zhou JH","Ge R","Schall U","Andreassen OA","Colibazzi T","Nelson B","Chen X","Salisbury DF","Loewy RL","Moller P","Fortea A","Theodoridou A","Michel C","Tamnes CK","Hayes RA","Chee MW","Thompson PM","Kwak YB","McGorry P","Suzuki M","Ma X","Koppel A","Frangou S","Kwon JS","Choi S","Fusar-Poli P","Takahashi T","Yung AR","ENIGMA Clinical High Risk for Psychosis Working Group","Kindler J","Hwang WJ","Glenthoj BY","Mizrahi R","Mizuno M","Katagiri N","Uhlhaas PJ","Baeza I","McGuire P","Hubl D","Jahanshad N","Haut KM","Omelchenko MA","Smigielski L","Rossler W","Kasai K","Nemoto T","Bartholomeusz CF","Lebedeva I","Thomopoulos SI","Horton LE","Glenthoj LB","Sugranyes G","Corcoran CM"],"additional_accession":[]},"is_claimable":false,"name":"Normative Modeling of Brain Morphometry in Clinical High Risk for Psychosis.","description":"<h4>Importance</h4>The lack of robust neuroanatomical markers of psychosis risk has been traditionally attributed to heterogeneity. A complementary hypothesis is that variation in neuroanatomical measures in individuals at psychosis risk may be nested within the range observed in healthy individuals.<h4>Objective</h4>To quantify deviations from the normative range of neuroanatomical variation in individuals at clinical high risk for psychosis (CHR-P) and evaluate their overlap with healthy variation and their association with positive symptoms, cognition, and conversion to a psychotic disorder.<h4>Design, setting, and participants</h4>This case-control study used clinical-, IQ-, and neuroimaging software (FreeSurfer)-derived regional measures of cortical thickness (CT), cortical surface ar","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2026-07-14T16:37:06.154Z","creation":"2025-04-06T16:00:06.25Z"},"accession":"S-EPMC10568447","cross_references":{"pubmed":["37819650"],"doi":["10.1001/jamapsychiatry.2023.3850"]}}