biostudies-literatureENIGMA Clinical High Risk for Psychosis Working GroupNCATS NIH HHSNIBIB NIH HHSNIMH NIH HHSMedical Research CouncilNational Institute for Health Research (NIHR)Lundbeck Foundation77-88https://www.ebi.ac.uk/biostudies/studies/S-EPMC10568447biostudies-literatureUnknown81(1)<h4>Importance</h4>The lack of robust neuroanatomical markers of psychosis risk has been traditionally attributed to heterogeneity. A complementary hypothesis is that variation in neuroanatomical measures in individuals at psychosis risk may be nested within the range observed in healthy individuals.<h4>Objective</h4>To quantify deviations from the normative range of neuroanatomical variation in individuals at clinical high risk for psychosis (CHR-P) and evaluate their overlap with healthy variation and their association with positive symptoms, cognition, and conversion to a psychotic disorder.<h4>Design, setting, and participants</h4>This case-control study used clinical-, IQ-, and neuroimaging software (FreeSurfer)-derived regional measures of cortical thickness (CT), cortical surface arJAMA psychiatryNormative Modeling of Brain Morphometry in Clinical High Risk for Psychosis.PMC10568447R01 MH113564R01 MH113533UL1 TR004419R01 MH115031NIHR-INF-0779R287-2018-1485T32 MH015144U54 EB020403R01 MH115332R01 MH116147R01 MH129636R01 MH123163T32 MH122394K23 MH085063R01 MH076989R21 MH117434MR/L011689/1R01 MH105246K01 MH112774R01 MH100043Ebdrup BHKahn RSSorensen MEKaess MMathalon DHPariente JCJalbrzikowski MRasser PEHegelstad WTVSchiffman JWenneberg CBachman PKoike SWaltz JALeon-Ortiz PYuan Lvan Amelsvoort TAMJWestlye LTLin AHe YMora-Duran RBaldwin HPantelis CVelakoulis DRaghava JMHamilton HKCropley VLHaas SSLee JSasabayashi DKim MKristensen TDResch FTang JVærnes TGHooker CIYamasue HVinogradov SLemmers-Jansen ILJAmminger GPHernaus DAgartz INordholm DWood SJCooper RERossberg JITomyshev ASAllen Pvan Erp TGMKlaunig MJReyes-Madrigal FLawrie SMOuyang Lde Haan Lde la Fuente-Sandoval CHeekeren KNordentoft MZhou JHGe RSchall UAndreassen OAColibazzi TNelson BChen XSalisbury DFLoewy RLMoller PFortea ATheodoridou AMichel CTamnes CKHayes RAChee MWThompson PMKwak YBMcGorry PSuzuki MMa XKoppel AFrangou SKwon JSChoi SFusar-Poli PTakahashi TYung ARENIGMA Clinical High Risk for Psychosis Working GroupKindler JHwang WJGlenthoj BYMizrahi RMizuno MKatagiri NUhlhaas PJBaeza IMcGuire PHubl DJahanshad NHaut KMOmelchenko MASmigielski LRossler WKasai KNemoto TBartholomeusz CFLebedeva IThomopoulos SIHorton LEGlenthoj LBSugranyes GCorcoran CMfalseNormative Modeling of Brain Morphometry in Clinical High Risk for Psychosis.<h4>Importance</h4>The lack of robust neuroanatomical markers of psychosis risk has been traditionally attributed to heterogeneity. A complementary hypothesis is that variation in neuroanatomical measures in individuals at psychosis risk may be nested within the range observed in healthy individuals.<h4>Objective</h4>To quantify deviations from the normative range of neuroanatomical variation in individuals at clinical high risk for psychosis (CHR-P) and evaluate their overlap with healthy variation and their association with positive symptoms, cognition, and conversion to a psychotic disorder.<h4>Design, setting, and participants</h4>This case-control study used clinical-, IQ-, and neuroimaging software (FreeSurfer)-derived regional measures of cortical thickness (CT), cortical surface ar2024-01-01T00:00:00Z2024 Jan2026-07-14T16:37:06.154Z2025-04-06T16:00:06.25ZS-EPMC105684473781965010.1001/jamapsychiatry.2023.3850