{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["102(12)"],"submitter":["He Y"],"pubmed_abstract":["Marek's disease virus (MDV), a naturally oncogenic, highly contagious alpha herpesvirus, induces a T cell lymphoma in chickens that causes severe economic loss. Marek's disease (MD) outcome in an individual is attributed to genetic and environmental factors. Further investigation of the host-virus interaction mechanisms that impact MD resistance is needed to achieve greater MD control. This study analyzed genome-wide DNA methylation patterns in 2 highly inbred parental lines 6<sub>3</sub> and 7<sub>2</sub> and 5 recombinant congenic strains (RCS) C, L, M, N, and X strains from those parents. Lines 6<sub>3</sub> and 7<sub>2</sub>, are MD resistant and susceptible, respectively, whereas the RCS have different combinations of 87.5% Line 6<sub>3</sub> and 12.5% Line 7<sub>2</sub>. Our DNA meth"],"journal":["Poultry science"],"pagination":["103036"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10568563"],"repository":["biostudies-literature"],"pubmed_title":["Transgenerational epigenetic inheritance and immunity in chickens that vary in Marek's disease resistance."],"pmcid":["PMC10568563"],"pubmed_authors":["Li Y","Taylor RL","He Y","Ashwell CM","Zhang H","Sun G","Zhao K","Bai H","Song J"],"additional_accession":[]},"is_claimable":false,"name":"Transgenerational epigenetic inheritance and immunity in chickens that vary in Marek's disease resistance.","description":"Marek's disease virus (MDV), a naturally oncogenic, highly contagious alpha herpesvirus, induces a T cell lymphoma in chickens that causes severe economic loss. Marek's disease (MD) outcome in an individual is attributed to genetic and environmental factors. Further investigation of the host-virus interaction mechanisms that impact MD resistance is needed to achieve greater MD control. This study analyzed genome-wide DNA methylation patterns in 2 highly inbred parental lines 6<sub>3</sub> and 7<sub>2</sub> and 5 recombinant congenic strains (RCS) C, L, M, N, and X strains from those parents. Lines 6<sub>3</sub> and 7<sub>2</sub>, are MD resistant and susceptible, respectively, whereas the RCS have different combinations of 87.5% Line 6<sub>3</sub> and 12.5% Line 7<sub>2</sub>. Our DNA meth","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2025-04-05T08:25:20.215Z","creation":"2025-04-05T08:25:20.215Z"},"accession":"S-EPMC10568563","cross_references":{"pubmed":["37832188"],"doi":["10.1016/j.psj.2023.103036"]}}