biostudies-literatureUnknown102(12)He YMarek's disease virus (MDV), a naturally oncogenic, highly contagious alpha herpesvirus, induces a T cell lymphoma in chickens that causes severe economic loss. Marek's disease (MD) outcome in an individual is attributed to genetic and environmental factors. Further investigation of the host-virus interaction mechanisms that impact MD resistance is needed to achieve greater MD control. This study analyzed genome-wide DNA methylation patterns in 2 highly inbred parental lines 6₃ and 7₂ and 5 recombinant congenic strains (RCS) C, L, M, N, and X strains from those parents. Lines 6₃ and 7₂, are MD resistant and susceptible, respectively, whereas the RCS have different combinations of 87.5% Line 6₃ and 12.5% Line 7₂. Our DNA methPoultry science103036https://www.ebi.ac.uk/biostudies/studies/S-EPMC10568563biostudies-literatureTransgenerational epigenetic inheritance and immunity in chickens that vary in Marek's disease resistance.PMC10568563Li YTaylor RLHe YAshwell CMZhang HSun GZhao KBai HSong JfalseTransgenerational epigenetic inheritance and immunity in chickens that vary in Marek's disease resistance.Marek's disease virus (MDV), a naturally oncogenic, highly contagious alpha herpesvirus, induces a T cell lymphoma in chickens that causes severe economic loss. Marek's disease (MD) outcome in an individual is attributed to genetic and environmental factors. Further investigation of the host-virus interaction mechanisms that impact MD resistance is needed to achieve greater MD control. This study analyzed genome-wide DNA methylation patterns in 2 highly inbred parental lines 6₃ and 7₂ and 5 recombinant congenic strains (RCS) C, L, M, N, and X strains from those parents. Lines 6₃ and 7₂, are MD resistant and susceptible, respectively, whereas the RCS have different combinations of 87.5% Line 6₃ and 12.5% Line 7₂. Our DNA meth2023-01-01T00:00:00Z2023 Aug2025-04-05T08:25:20.215Z2025-04-05T08:25:20.215ZS-EPMC105685633783218810.1016/j.psj.2023.103036