{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Seo G"],"funding":["NCI NIH HHS","NIGMS NIH HHS"],"pagination":["3155-3170.e8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10568779"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["83(17)"],"pubmed_abstract":["The Hippo pathway is known for its crucial involvement in development, regeneration, organ size control, and cancer. While energy stress is known to activate the Hippo pathway and inhibit its effector YAP, the precise role of the Hippo pathway in energy stress response remains unclear. Here, we report a YAP-independent function of the Hippo pathway in facilitating autophagy and cell survival in response to energy stress, a process mediated by its upstream components MAP4K2 and STRIPAK. Mechanistically, energy stress disrupts the MAP4K2-STRIPAK association, leading to the activation of MAP4K2. Subsequently, MAP4K2 phosphorylates ATG8-family member LC3, thereby facilitating autophagic flux. MAP4K2 is highly expressed in head and neck cancer, and its mediated autophagy is required for head an"],"journal":["Molecular cell"],"pubmed_title":["The Hippo pathway noncanonically drives autophagy and cell survival in response to energy stress."],"pmcid":["PMC10568779"],"funding_grant_id":["R35 GM145249","P30 CA062203","R01 GM074830","R01 GM126048","R01 GM143233"],"pubmed_authors":["Luo A","Edwards R","Seo G","An J","Kizhedathu A","Yang B","Huang L","Xing L","Tifrea D","Yu C","Ju HQ","Han H","Buckle AL","Wang W","Kattan RE"],"additional_accession":[]},"is_claimable":false,"name":"The Hippo pathway noncanonically drives autophagy and cell survival in response to energy stress.","description":"The Hippo pathway is known for its crucial involvement in development, regeneration, organ size control, and cancer. While energy stress is known to activate the Hippo pathway and inhibit its effector YAP, the precise role of the Hippo pathway in energy stress response remains unclear. Here, we report a YAP-independent function of the Hippo pathway in facilitating autophagy and cell survival in response to energy stress, a process mediated by its upstream components MAP4K2 and STRIPAK. Mechanistically, energy stress disrupts the MAP4K2-STRIPAK association, leading to the activation of MAP4K2. Subsequently, MAP4K2 phosphorylates ATG8-family member LC3, thereby facilitating autophagic flux. MAP4K2 is highly expressed in head and neck cancer, and its mediated autophagy is required for head an","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2026-06-01T06:47:30.16Z","creation":"2025-02-19T02:33:35.538Z"},"accession":"S-EPMC10568779","cross_references":{"pubmed":["37595580"],"doi":["10.1016/j.molcel.2023.07.019"]}}