biostudies-literatureUnknownYang CResearch Grants Council, University Grants CommitteeNational Natural Science Fund in ChinaShenzhen Key Project for Basic ResearchIn this work, we collected foodborne <i>Salmonella</i> strains in Shenzhen, China, during 2014-2017 and investigated the genetic profile of all cefotaxime-resistant isolates in the collection. The strains were subjected to antimicrobial susceptibility tests, whole-genome sequencing, bioinformatics analysis, and conjugation studies. A total of 79 cefotaxime-resistant <i>Salmonella</i> were identified and found to exhibit multidrug resistance. Resistance rate recorded during the study period increased from 1.9% to 9.1%. <i>Salmonella</i> Typhimurium was the predominant serovar, and CTX-M family genes were dominant among the ESBLs genes detected. Notably, CTX-M-bearing plasmids or transposons often contain other drug resistance genes. Furthermore, a combination of CTX-M-55 and CTX-M-65 genes Microbiology spectrume0488622https://www.ebi.ac.uk/biostudies/studies/S-EPMC10580925biostudies-literaturePrevalence and molecular characterization of cefotaxime-resistant <i>Salmonella</i> strains recovered from retail meat samples in Shenzhen, China, during 2014-2017.PMC10580925JCYJ20200109143220716N_PolyU521/18NSFC-RGCYang XYe LHeng HChen KWai-Chi Chan EChen SYang CfalsePrevalence and molecular characterization of cefotaxime-resistant <i>Salmonella</i> strains recovered from retail meat samples in Shenzhen, China, during 2014-2017.In this work, we collected foodborne <i>Salmonella</i> strains in Shenzhen, China, during 2014-2017 and investigated the genetic profile of all cefotaxime-resistant isolates in the collection. The strains were subjected to antimicrobial susceptibility tests, whole-genome sequencing, bioinformatics analysis, and conjugation studies. A total of 79 cefotaxime-resistant <i>Salmonella</i> were identified and found to exhibit multidrug resistance. Resistance rate recorded during the study period increased from 1.9% to 9.1%. <i>Salmonella</i> Typhimurium was the predominant serovar, and CTX-M family genes were dominant among the ESBLs genes detected. Notably, CTX-M-bearing plasmids or transposons often contain other drug resistance genes. Furthermore, a combination of CTX-M-55 and CTX-M-65 genes 2023-01-01T00:00:00Z2023 Aug2026-05-28T11:14:40.765Z2025-04-06T02:09:00.308ZS-EPMC105809253761543910.1128/spectrum.04886-22