biostudies-literatureUnknown20(12)Wang LUterine Corpus Endometrial Carcinoma (UCEC) is one of the major malignant tumors of the female reproductive system. However, there are limitations in the currently available diagnostic approaches for UCEC. Long non-coding RNAs (lncRNAs) play important roles in regulating biological processes as competitive endogenous RNA (ceRNA) in tumors. To study the potential of lncRNAs as non-invasive diagnostic tumor markers, RNA-sequencing dataset of UCEC patients from The Cancer Genome Atlas was used to identify differentially expressed genes. A lncRNA-miRNA-mRNA ceRNA network was constructed by differentially expressed lncRNAs, miRNAs and miRNAs. Pathway enrichment and functional analysis for the mRNAs in the constructed ceRNA network provide the direction of future research for UCEC by demonstratiInternational journal of medical sciences1600-1615https://www.ebi.ac.uk/biostudies/studies/S-EPMC10583181biostudies-literatureIdentification of lncRNAs associated with uterine corpus endometrial cancer prognosis based on the competing endogenous RNA network.PMC10583181Xiong ZYang GLu GLuo JZhang XLeung GHDZhai LLiu QWang YSu XWang LZhou JfalseIdentification of lncRNAs associated with uterine corpus endometrial cancer prognosis based on the competing endogenous RNA network.Uterine Corpus Endometrial Carcinoma (UCEC) is one of the major malignant tumors of the female reproductive system. However, there are limitations in the currently available diagnostic approaches for UCEC. Long non-coding RNAs (lncRNAs) play important roles in regulating biological processes as competitive endogenous RNA (ceRNA) in tumors. To study the potential of lncRNAs as non-invasive diagnostic tumor markers, RNA-sequencing dataset of UCEC patients from The Cancer Genome Atlas was used to identify differentially expressed genes. A lncRNA-miRNA-mRNA ceRNA network was constructed by differentially expressed lncRNAs, miRNAs and miRNAs. Pathway enrichment and functional analysis for the mRNAs in the constructed ceRNA network provide the direction of future research for UCEC by demonstrati2023-01-01T00:00:00Z20232026-05-29T07:32:18.018Z2025-04-04T11:00:50.88ZS-EPMC105831813785969710.7150/ijms.87430