biostudies-literatureChowdhury ASNational Institute of General Medical SciencesNIGMS NIH HHS572-577https://www.ebi.ac.uk/biostudies/studies/S-EPMC10586751biostudies-literatureUnknown2022Collagen α1(XI) is a minor fibrillar collagen involved in the critical regulation of collagen fibrils such as nucleation, assembly, and regulation of fibril diameter. The amino propeptide domain of the collagen α1(XI) is retained on the surface of the collagen fibril for an extended period of time and may play a crucial role in the interaction with extracellular matrix glycosaminoglycans and other proteins during the process of fibrillogenesis. Understanding the mechanism of action of this protein will ultimately help us understand the organization and assembly of the extracellular matrix that underlies the structural integrity of connective tissues.Proceedings. International Conference on Computational Science and Computational IntelligenceCollagen a1(XI) structure prediction by Alphafold 2.PMC10586751P20 GM109095P20 GM103408Oxford JTChowdhury ASfalseCollagen a1(XI) structure prediction by Alphafold 2.Collagen α1(XI) is a minor fibrillar collagen involved in the critical regulation of collagen fibrils such as nucleation, assembly, and regulation of fibril diameter. The amino propeptide domain of the collagen α1(XI) is retained on the surface of the collagen fibril for an extended period of time and may play a crucial role in the interaction with extracellular matrix glycosaminoglycans and other proteins during the process of fibrillogenesis. Understanding the mechanism of action of this protein will ultimately help us understand the organization and assembly of the extracellular matrix that underlies the structural integrity of connective tissues.2022-01-01T00:00:00Z2022 Dec2025-04-04T07:25:31.499Z2025-04-04T07:25:31.499ZS-EPMC105867513786074710.1109/csci58124.2022.00108