biostudies-literatureKumar PEuropean Research CouncilBrisSynBioIsrael Science FoundationBiotechnology and Biological Sciences Research Councile4789https://www.ebi.ac.uk/biostudies/studies/S-EPMC10588367biostudies-literatureUnknown32(11)α-Helical coiled coils are common tertiary and quaternary elements of protein structure. In coiled coils, two or more α helices wrap around each other to form bundles. This apparently simple structural motif can generate many architectures and topologies. Coiled coil-forming sequences can be predicted from heptad repeats of hydrophobic and polar residues, hpphppp, although this is not always reliable. Alternatively, coiled-coil structures can be identified using the program SOCKET, which finds knobs-into-holes (KIH) packing between side chains of neighboring helices. SOCKET also classifies coiled-coil architecture and topology, thus allowing sequence-to-structure relationships to be garnered. In 2009, we used SOCKET to create a relational database of coiled-coil structures, CC⁺ Protein science : a publication of the Protein SocietyCC⁺ : A searchable database of validated coiled coils in PDB structures and AlphaFold2 models.PMC10588367819318BB/L01386X/11452/18340764787173BB/R00661X/1Schweke HPetrenas RLevy EDWoolfson DNKumar PDawson WMfalseCC⁺ : A searchable database of validated coiled coils in PDB structures and AlphaFold2 models.α-Helical coiled coils are common tertiary and quaternary elements of protein structure. In coiled coils, two or more α helices wrap around each other to form bundles. This apparently simple structural motif can generate many architectures and topologies. Coiled coil-forming sequences can be predicted from heptad repeats of hydrophobic and polar residues, hpphppp, although this is not always reliable. Alternatively, coiled-coil structures can be identified using the program SOCKET, which finds knobs-into-holes (KIH) packing between side chains of neighboring helices. SOCKET also classifies coiled-coil architecture and topology, thus allowing sequence-to-structure relationships to be garnered. In 2009, we used SOCKET to create a relational database of coiled-coil structures, CC⁺ 2023-01-01T00:00:00Z2023 Nov2026-05-28T18:14:07.678Z2025-02-19T01:52:56.062ZS-EPMC105883673776827110.1002/pro.4789