{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lang A"],"funding":["NIAID NIH HHS","NCI NIH HHS"],"pagination":["933-939"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10592152"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["152(4)"],"pubmed_abstract":["<h4>Background</h4>Increased TPSAB1 copy numbers encoding ⍺-tryptase are associated with severe reactions in adults with Hymenoptera venom allergy, systemic mastocytosis, and idiopathic anaphylaxis.<h4>Objective</h4>The primary objective was to assess the association between ⍺-tryptase and severity of food allergy.<h4>Methods</h4>A total of 119 subjects underwent tryptase genotyping; 82 of them were from an observational food allergy cohort at the National Institute of Allergy and Infectious Disease (NIAID), and 37 were from a cohort of children who reacted to peanut oral food challenge (OFC) at Lurie Children's Hospital of Chicago. The primary predictor was presence or absence of ⍺-tryptase. The primary outcomes for both cohorts were measures of severity of food allergy reaction. Secondar"],"journal":["The Journal of allergy and clinical immunology"],"pubmed_title":["Severe food allergy reactions are associated with α-tryptase."],"pmcid":["PMC10592152"],"funding_grant_id":["SI2 AI138586","75N91019D00024","T32 AI083216"],"pubmed_authors":["Pongracic J","Liu Y","Lyons JJ","Kubala S","Lang A","Mateja A","Frischmeyer-Guerrerio PA","Grieco MC","Kumar R"],"additional_accession":[]},"is_claimable":false,"name":"Severe food allergy reactions are associated with α-tryptase.","description":"<h4>Background</h4>Increased TPSAB1 copy numbers encoding ⍺-tryptase are associated with severe reactions in adults with Hymenoptera venom allergy, systemic mastocytosis, and idiopathic anaphylaxis.<h4>Objective</h4>The primary objective was to assess the association between ⍺-tryptase and severity of food allergy.<h4>Methods</h4>A total of 119 subjects underwent tryptase genotyping; 82 of them were from an observational food allergy cohort at the National Institute of Allergy and Infectious Disease (NIAID), and 37 were from a cohort of children who reacted to peanut oral food challenge (OFC) at Lurie Children's Hospital of Chicago. The primary predictor was presence or absence of ⍺-tryptase. The primary outcomes for both cohorts were measures of severity of food allergy reaction. Secondar","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Oct","modification":"2026-06-03T03:43:54.306Z","creation":"2025-04-05T23:46:18.593Z"},"accession":"S-EPMC10592152","cross_references":{"pubmed":["37558059"],"doi":["10.1016/j.jaci.2023.07.014"]}}