biostudies-literatureLang ANIAID NIH HHSNCI NIH HHS933-939https://www.ebi.ac.uk/biostudies/studies/S-EPMC10592152biostudies-literatureUnknown152(4)<h4>Background</h4>Increased TPSAB1 copy numbers encoding ⍺-tryptase are associated with severe reactions in adults with Hymenoptera venom allergy, systemic mastocytosis, and idiopathic anaphylaxis.<h4>Objective</h4>The primary objective was to assess the association between ⍺-tryptase and severity of food allergy.<h4>Methods</h4>A total of 119 subjects underwent tryptase genotyping; 82 of them were from an observational food allergy cohort at the National Institute of Allergy and Infectious Disease (NIAID), and 37 were from a cohort of children who reacted to peanut oral food challenge (OFC) at Lurie Children's Hospital of Chicago. The primary predictor was presence or absence of ⍺-tryptase. The primary outcomes for both cohorts were measures of severity of food allergy reaction. SecondarThe Journal of allergy and clinical immunologySevere food allergy reactions are associated with α-tryptase.PMC10592152SI2 AI13858675N91019D00024T32 AI083216Pongracic JLiu YLyons JJKubala SLang AMateja AFrischmeyer-Guerrerio PAGrieco MCKumar RfalseSevere food allergy reactions are associated with α-tryptase.<h4>Background</h4>Increased TPSAB1 copy numbers encoding ⍺-tryptase are associated with severe reactions in adults with Hymenoptera venom allergy, systemic mastocytosis, and idiopathic anaphylaxis.<h4>Objective</h4>The primary objective was to assess the association between ⍺-tryptase and severity of food allergy.<h4>Methods</h4>A total of 119 subjects underwent tryptase genotyping; 82 of them were from an observational food allergy cohort at the National Institute of Allergy and Infectious Disease (NIAID), and 37 were from a cohort of children who reacted to peanut oral food challenge (OFC) at Lurie Children's Hospital of Chicago. The primary predictor was presence or absence of ⍺-tryptase. The primary outcomes for both cohorts were measures of severity of food allergy reaction. Secondar2023-01-01T00:00:00Z2023 Oct2026-06-03T03:43:54.306Z2025-04-05T23:46:18.593ZS-EPMC105921523755805910.1016/j.jaci.2023.07.014