{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["1(4)"],"submitter":["Liu Z"],"funding":["China Scholarship Council","Fraunhofer-Gesellschaft","Horizon 2020 Framework Programme"],"pubmed_abstract":["The uptake and the fate of Zr-based metal-organic-framework nanoparticles labeled with organic fluorophores in HeLa cells has been monitored with fluorescence detection and elemental analysis. The nanoparticles have been selected as a model system of carrier nanoparticles (here Zr-based metal-organic-framework nanoparticles) with integrated cargo molecules (here organic fluorophores), with aze that does not allow for efficient exocytosis, a material which only partly degrades under acidic conditions as present in endosomes/lysosomes, and with limited colloidal stability. Data show that, for Zr-based metal-organic-framework nanoparticles of 40 nm size as investigated here, the number of nanoparticles per cells decreases faster due to particle redistribution upon proliferation than due to na"],"journal":["Environment & health (Washington, D.C.)"],"pagination":["270-277"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10594580"],"repository":["biostudies-literature"],"pubmed_title":["Uptake and Intracellular Fate of Fluorophore Labeled Metal-Organic-Framework (MOF) Nanoparticles."],"pmcid":["PMC10594580"],"pubmed_authors":["Chakraborty I","Liu Z","Parak WJ","Feliu N","Zimpel A","Pozzi M","Lachelt U","Gonzalez MG","Wuttke S"],"additional_accession":[]},"is_claimable":false,"name":"Uptake and Intracellular Fate of Fluorophore Labeled Metal-Organic-Framework (MOF) Nanoparticles.","description":"The uptake and the fate of Zr-based metal-organic-framework nanoparticles labeled with organic fluorophores in HeLa cells has been monitored with fluorescence detection and elemental analysis. The nanoparticles have been selected as a model system of carrier nanoparticles (here Zr-based metal-organic-framework nanoparticles) with integrated cargo molecules (here organic fluorophores), with aze that does not allow for efficient exocytosis, a material which only partly degrades under acidic conditions as present in endosomes/lysosomes, and with limited colloidal stability. Data show that, for Zr-based metal-organic-framework nanoparticles of 40 nm size as investigated here, the number of nanoparticles per cells decreases faster due to particle redistribution upon proliferation than due to na","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Oct","modification":"2026-03-18T14:09:14.412Z","creation":"2025-04-05T11:48:00.84Z"},"accession":"S-EPMC10594580","cross_references":{"pubmed":["37881592"],"doi":["10.1021/envhealth.3c00075"]}}