{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nimerovsky E"],"funding":["Deutsche Forschungsgemeinschaft","Max-Planck-Gesellschaft"],"pagination":["2763-2771"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10598565"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(10)"],"pubmed_abstract":["Inspired by the recently proposed transverse mixing optimal control pulses (TROP) approach for improving signal in multidimensional magic-angle spinning (MAS) NMR experiments, we present simplified preservation of equivalent pathways spectroscopy (SPEPS). It transfers both transverse components of magnetization that occur during indirect evolutions, theoretically enabling a √2 improvement in sensitivity for each such dimension. We compare SPEPS transfer with TROP and cross-polarization (CP) using membrane protein and fibril samples at MAS of 55 and 100 kHz. In three-dimensional (3D) (H)CANH spectra, SPEPS outperformed TROP and CP by factors of on average 1.16 and 1.69, respectively, for the membrane protein, but only a marginal improvement of 1.09 was observed for the fibril. These differe"],"journal":["JACS Au"],"pubmed_title":["Simplified Preservation of Equivalent Pathways Spectroscopy."],"pmcid":["PMC10598565"],"funding_grant_id":["AN1316"],"pubmed_authors":["Andreas LB","Varkey AC","Becker S","Kim M","Nimerovsky E"],"additional_accession":[]},"is_claimable":false,"name":"Simplified Preservation of Equivalent Pathways Spectroscopy.","description":"Inspired by the recently proposed transverse mixing optimal control pulses (TROP) approach for improving signal in multidimensional magic-angle spinning (MAS) NMR experiments, we present simplified preservation of equivalent pathways spectroscopy (SPEPS). It transfers both transverse components of magnetization that occur during indirect evolutions, theoretically enabling a √2 improvement in sensitivity for each such dimension. We compare SPEPS transfer with TROP and cross-polarization (CP) using membrane protein and fibril samples at MAS of 55 and 100 kHz. In three-dimensional (3D) (H)CANH spectra, SPEPS outperformed TROP and CP by factors of on average 1.16 and 1.69, respectively, for the membrane protein, but only a marginal improvement of 1.09 was observed for the fibril. These differe","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Oct","modification":"2026-05-29T07:34:18.238Z","creation":"2026-05-16T03:07:34.458Z"},"accession":"S-EPMC10598565","cross_references":{"pubmed":["37885577"],"doi":["10.1021/jacsau.3c00312"]}}