biostudies-literatureRodriguez-Calienes ANCATS NIH HHSNINDS NIH HHSNIGMS NIH HHS2522-2533https://www.ebi.ac.uk/biostudies/studies/S-EPMC10599264biostudies-literatureUnknown54(10)<h4>Background</h4>We aimed to describe the safety and efficacy of mechanical thrombectomy (MT) with or without intravenous thrombolysis (IVT) for patients with tandem lesions and whether using intraprocedural antiplatelet therapy influences MT's safety with IVT treatment.<h4>Methods</h4>This is a subanalysis of a pooled, multicenter cohort of patients with acute anterior circulation tandem lesions treated with MT from 16 stroke centers between January 2015 and December 2020. Primary outcomes included symptomatic intracranial hemorrhage (sICH) and parenchymal hematoma type 2. Additional outcomes included hemorrhagic transformation, successful reperfusion (modified Thrombolysis in Cerebral Infarction score 2b-3), complete reperfusion (modified Thrombolysis in Cerebral Infarction score 3), fStrokeSafety Outcomes of Mechanical Thrombectomy Versus Combined Thrombectomy and Intravenous Thrombolysis in Tandem Lesions.PMC10599264R03 NS126804K23 NS110980R21 NS130423UL1 TR001863R01 NS127114P20 GM109089Rizzo FMokin MMalik AMQureshi AIkram AAbdalkader MFarooqui MSiegler JEGordon WSheth SAbraham MJanjua NHassan AETurabova CNguyen TNYoo AJQuispe-Orozco DVivanco-Suarez JBegunova LJumaa MAVigilante NLinares GMatsouka SPetersen NHYavagal DRGuerrero WRJovin TSalazar-Marioni SRibo MTekle WGRodriguez-Calienes AGalecio-Castillo MSoomro JOrtega-Gutierrez SDivani AAFifi JAlhajala HfalseSafety Outcomes of Mechanical Thrombectomy Versus Combined Thrombectomy and Intravenous Thrombolysis in Tandem Lesions.<h4>Background</h4>We aimed to describe the safety and efficacy of mechanical thrombectomy (MT) with or without intravenous thrombolysis (IVT) for patients with tandem lesions and whether using intraprocedural antiplatelet therapy influences MT's safety with IVT treatment.<h4>Methods</h4>This is a subanalysis of a pooled, multicenter cohort of patients with acute anterior circulation tandem lesions treated with MT from 16 stroke centers between January 2015 and December 2020. Primary outcomes included symptomatic intracranial hemorrhage (sICH) and parenchymal hematoma type 2. Additional outcomes included hemorrhagic transformation, successful reperfusion (modified Thrombolysis in Cerebral Infarction score 2b-3), complete reperfusion (modified Thrombolysis in Cerebral Infarction score 3), f2023-01-01T00:00:00Z2023 Oct2026-06-01T22:15:52.139Z2025-04-04T00:34:18.318ZS-EPMC105992643760238710.1161/STROKEAHA.123.04296610.1161/strokeaha.123.042966