{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yoon H"],"funding":["City University of New York","NCATS","NCATS NIH HHS","NIAID NIH HHS","National Institutes of Health","Wellcome Trust","NIH HHS"],"pagination":["myad102"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10599321"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["61(10)"],"pubmed_abstract":["Host non-T cell markers to aid in the diagnosis of cryptococcal meningoencephalitis (CM) have not been identified. In this case-control study, we characterized antibody and B cell profiles in HIV-negative and HIV-positive Vietnamese individuals of the Kinh ethnicity recently diagnosed with CM and controls. The study included 60 HIV-negative with no known immunocompromising condition and 60 HIV-positive individuals, with 30 CM cases and 30 controls in each group. Participants were matched by age, sex, HIV serostatus, and CD4 count in the HIV-positive group. Plasma immunoglobulin (Ig) levels, including IgG1, IgG2, IgM, and IgA, Cryptococcus spp. glucuronoxylomannan (GXM)- and laminarin (branched ${\\rm{\\beta }}$-[1-3]-glucan)-binding IgG, IgM, IgA levels, and peripheral blood B cell subsets w"],"journal":["Medical mycology"],"pubmed_title":["Shared and unique antibody and B cell profiles in HIV-positive and HIV-negative individuals with cryptococcal meningoencephalitis."],"pmcid":["PMC10599321"],"funding_grant_id":["R01-AI143453","UL1TH001073","P30-AI124414","R01 AI143453","WT097147MA","S10 OD026833","P30 AI124414"],"pubmed_authors":["Yoon H","Duong VA","Pirofski LA","Tung NLN","Hung LQ","Binh TQ","Nakouzi AS","Day JN"],"additional_accession":[]},"is_claimable":false,"name":"Shared and unique antibody and B cell profiles in HIV-positive and HIV-negative individuals with cryptococcal meningoencephalitis.","description":"Host non-T cell markers to aid in the diagnosis of cryptococcal meningoencephalitis (CM) have not been identified. In this case-control study, we characterized antibody and B cell profiles in HIV-negative and HIV-positive Vietnamese individuals of the Kinh ethnicity recently diagnosed with CM and controls. The study included 60 HIV-negative with no known immunocompromising condition and 60 HIV-positive individuals, with 30 CM cases and 30 controls in each group. Participants were matched by age, sex, HIV serostatus, and CD4 count in the HIV-positive group. Plasma immunoglobulin (Ig) levels, including IgG1, IgG2, IgM, and IgA, Cryptococcus spp. glucuronoxylomannan (GXM)- and laminarin (branched ${\\rm{\\beta }}$-[1-3]-glucan)-binding IgG, IgM, IgA levels, and peripheral blood B cell subsets w","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Oct","modification":"2026-06-05T05:46:47.743Z","creation":"2025-04-20T00:45:59.043Z"},"accession":"S-EPMC10599321","cross_references":{"pubmed":["37771088"],"doi":["10.1093/mmy/myad102"]}}