biostudies-literatureUnknown2023Pinho-Jr JDS<h4>Background</h4>Overweight and obesity are global health issues, impacting a significant portion of young adults. Obesity is a complex condition influenced by genetics and environmental factors, leading to increased susceptibility to cardiovascular diseases (CVDs), hypertension, dyslipidemia, and insulin resistance. Irisin, a protein derived from the cleavage of fibronectin type III domain-containing protein 5, may have relationship with these cardiometabolic diseases.<h4>Objective</h4>This systematic review aims to examine the relationship between serum irisin levels and obesity, particularly in individuals predisposed to cardiovascular risk factors.<h4>Methods</h4>A thorough literature search was conducted in multiple databases, including "Science Direct," "Scopus," "PubMed," and "LilInternational journal of inflammation5810157https://www.ebi.ac.uk/biostudies/studies/S-EPMC10602702biostudies-literatureIrisin and Cardiometabolic Disorders in Obesity: A Systematic Review.PMC10602702Cavararo CDSMedeiros RFBarroso SGPinho-Jr JDSde Matos ACCamacho FABaiao PFfalseIrisin and Cardiometabolic Disorders in Obesity: A Systematic Review.<h4>Background</h4>Overweight and obesity are global health issues, impacting a significant portion of young adults. Obesity is a complex condition influenced by genetics and environmental factors, leading to increased susceptibility to cardiovascular diseases (CVDs), hypertension, dyslipidemia, and insulin resistance. Irisin, a protein derived from the cleavage of fibronectin type III domain-containing protein 5, may have relationship with these cardiometabolic diseases.<h4>Objective</h4>This systematic review aims to examine the relationship between serum irisin levels and obesity, particularly in individuals predisposed to cardiovascular risk factors.<h4>Methods</h4>A thorough literature search was conducted in multiple databases, including "Science Direct," "Scopus," "PubMed," and "Lil2023-01-01T00:00:00Z20232025-04-05T11:54:13.171Z2025-04-05T11:54:13.171ZS-EPMC106027023790097910.1155/2023/5810157