{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lim JS"],"funding":["Ministry of Education","Korea Food Research Institute (KFRI) funded by the Ministry of Science","National Research Foundation of Korea (NRF)","Ministry of Science","Korea Research Institute of Bioscience and Biotechnology (KRIBB) Research Initiative Program","National Research Foundation of Korea"],"pagination":["1792"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10604099"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(10)"],"pubmed_abstract":["<i>Ehretia tinifolia</i> (<i>E. tinifolia</i>) L., an evergreen tree with substantial biological activity, including antioxidant and anti-inflammatory effects, has been used in many herbal and traditional medicines. To elucidate its antioxidant and anti-inflammatory activity and the underlying mechanisms, we applied a methanol extract of <i>E. tinifolia</i> (ETME) to lipopolysaccharide (LPS)-stimulated mouse immortalized Kupffer cells. ETME suppressed the LPS-induced increase in nitric oxide, a mediator for oxidative stress and inflammation, and restored LPS-mediated depletion of total glutathione level by stabilizing antioxidative nuclear factor erythroid 2-related factor 2 (Nrf2) and the subsequent increase in heme oxygenase-1 levels. Furthermore, ETME inhibited the LPS-induced productio"],"journal":["Antioxidants (Basel, Switzerland)"],"pubmed_title":["Inhibitory Effects of <i>Ehretia tinifolia</i> Extract on the Excessive Oxidative and Inflammatory Responses in Lipopolysaccharide-Stimulated Mouse Kupffer Cells."],"pmcid":["PMC10604099"],"funding_grant_id":["Main Research Program E0210300","NRF-2020R1C1C1007261","E0210300","NRF-2022R1I1A1A01056975","KGM5242322"],"pubmed_authors":["Cho YC","Lim JS","Lee DY","Yun H","Lee SH","Bach TT","Cho N","Choi JU","Yoo G","Lee KY","Park SJ"],"additional_accession":[]},"is_claimable":false,"name":"Inhibitory Effects of <i>Ehretia tinifolia</i> Extract on the Excessive Oxidative and Inflammatory Responses in Lipopolysaccharide-Stimulated Mouse Kupffer Cells.","description":"<i>Ehretia tinifolia</i> (<i>E. tinifolia</i>) L., an evergreen tree with substantial biological activity, including antioxidant and anti-inflammatory effects, has been used in many herbal and traditional medicines. To elucidate its antioxidant and anti-inflammatory activity and the underlying mechanisms, we applied a methanol extract of <i>E. tinifolia</i> (ETME) to lipopolysaccharide (LPS)-stimulated mouse immortalized Kupffer cells. ETME suppressed the LPS-induced increase in nitric oxide, a mediator for oxidative stress and inflammation, and restored LPS-mediated depletion of total glutathione level by stabilizing antioxidative nuclear factor erythroid 2-related factor 2 (Nrf2) and the subsequent increase in heme oxygenase-1 levels. Furthermore, ETME inhibited the LPS-induced productio","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2026-06-22T03:21:57.989Z","creation":"2025-04-04T10:07:01.89Z"},"accession":"S-EPMC10604099","cross_references":{"pubmed":["37891872"],"doi":["10.3390/antiox12101792"]}}