biostudies-literatureKuhlmann HStiftung Universitätsmedizin Essen1167https://www.ebi.ac.uk/biostudies/studies/S-EPMC10604239biostudies-literatureUnknown10(10)Hyperspectral imaging (HSI) is a non-invasive technology that provides information on biochemical tissue properties, including skin oxygenation and perfusion quality. Microcirculatory alterations are associated with organ dysfunction in septic COVID-19 patients. This prospective observational study investigated associations between skin HSI and organ dysfunction severity in critically ill COVID-19 patients. During the first seven days in the ICU, palmar HSI measurements were carried out with the TIVITA^® tissue system. We report data from 52 critically ill COVID-19 patients, of whom 40 required extracorporeal membrane oxygenation (ECMO). HSI parameters for superficial tissue oxygenation (StO₂) and oxygenation and perfusion quality (NPI) were persistently decreased. HemBioengineering (Basel, Switzerland)Bedside Hyperspectral Imaging and Organ Dysfunction Severity in Critically Ill COVID-19 Patients-A Prospective, Monocentric Observational Study.PMC1060423920204699120Garczarek LKunne DBrenner TSchmidt BArends SPattberg KFrank MHerbstreit FKuhlmann HEspeter FSkarabis ASchmidt KfalseBedside Hyperspectral Imaging and Organ Dysfunction Severity in Critically Ill COVID-19 Patients-A Prospective, Monocentric Observational Study.Hyperspectral imaging (HSI) is a non-invasive technology that provides information on biochemical tissue properties, including skin oxygenation and perfusion quality. Microcirculatory alterations are associated with organ dysfunction in septic COVID-19 patients. This prospective observational study investigated associations between skin HSI and organ dysfunction severity in critically ill COVID-19 patients. During the first seven days in the ICU, palmar HSI measurements were carried out with the TIVITA^® tissue system. We report data from 52 critically ill COVID-19 patients, of whom 40 required extracorporeal membrane oxygenation (ECMO). HSI parameters for superficial tissue oxygenation (StO₂) and oxygenation and perfusion quality (NPI) were persistently decreased. Hem2023-01-01T00:00:00Z2023 Oct2025-04-04T10:06:47.412Z2025-04-04T10:06:47.412ZS-EPMC106042393789289710.3390/bioengineering10101167