{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang C"],"funding":["Der Regierende Bürgermeister von Berlin, Senatskanzlei Wissenschaft und Forschung","Ministerium für Kultur undWissenschaft des Landes Nordrhein-Westfalen","German Society of Orthopedics and Orthopedic Surgery (Deutsche Gesellschaft für Orthopädie und Orthopädische Chirurgie; DGOOC)","DGOOC"],"pagination":["2804"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10604262"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(10)"],"pubmed_abstract":["In orthopedics, musculoskeletal disorders, i.e., non-union of bone fractures or osteoporosis, can have common histories and symptoms related to pathological hypoxic conditions induced by aging, trauma or metabolic disorders. Here, we observed that hypoxic conditions (2% O<sub>2</sub>) suppressed the osteogenic differentiation of human bone marrow-derived mesenchymal cells (hBMSC) in vitro and simultaneously increased reactive oxygen species (ROS) production. We assumed that cellular origin and cargo of extracellular vesicles (EVs) affect the osteogenic differentiation capacity of hBMSCs cultured under different oxygen pressures. Proteomic analysis revealed that EVs isolated from osteogenic differentiated hBMSC cultured under hypoxia (hypo-osteo EVs) or under normoxia (norm-osteo EVs) conta"],"journal":["Biomedicines"],"pubmed_title":["Extracellular Vesicles Derived from Osteogenic-Differentiated Human Bone Marrow-Derived Mesenchymal Cells Rescue Osteogenic Ability of Bone Marrow-Derived Mesenchymal Cells Impaired by Hypoxia."],"pmcid":["PMC10604262"],"funding_grant_id":["SG"],"pubmed_authors":["Bauer RJ","Ilic J","Wang C","Hofmann K","Sickmann A","Pattappa G","Schulz D","Stockl S","Reinders Y","Grassel S"],"additional_accession":[]},"is_claimable":false,"name":"Extracellular Vesicles Derived from Osteogenic-Differentiated Human Bone Marrow-Derived Mesenchymal Cells Rescue Osteogenic Ability of Bone Marrow-Derived Mesenchymal Cells Impaired by Hypoxia.","description":"In orthopedics, musculoskeletal disorders, i.e., non-union of bone fractures or osteoporosis, can have common histories and symptoms related to pathological hypoxic conditions induced by aging, trauma or metabolic disorders. Here, we observed that hypoxic conditions (2% O<sub>2</sub>) suppressed the osteogenic differentiation of human bone marrow-derived mesenchymal cells (hBMSC) in vitro and simultaneously increased reactive oxygen species (ROS) production. We assumed that cellular origin and cargo of extracellular vesicles (EVs) affect the osteogenic differentiation capacity of hBMSCs cultured under different oxygen pressures. Proteomic analysis revealed that EVs isolated from osteogenic differentiated hBMSC cultured under hypoxia (hypo-osteo EVs) or under normoxia (norm-osteo EVs) conta","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Oct","modification":"2026-05-16T03:11:05.121Z","creation":"2025-04-04T10:07:09.578Z"},"accession":"S-EPMC10604262","cross_references":{"pubmed":["37893177"],"doi":["10.3390/biomedicines11102804"]}}