biostudies-literatureUnknown12(10)Groger AAging is characterized by a number of hallmarks including loss of mitochondrial homeostasis and decay in stress tolerance, among others. Unicellular eukaryotes have been widely used to study chronological aging. As a general trait, calorie restriction and activation of mitochondrial respiration has been proposed to contribute to an elongated lifespan. Most aging-related studies have been conducted with the Crabtree-positive yeasts <i>Saccharomyces cerevisiae</i> and <i>Schizosaccharomyces pombe</i>, and with deletion collections deriving from these conventional yeast models. We have performed an unbiased characterization of longevity using thirteen fungi species, including <i>S. cerevisiae</i> and <i>S. pombe</i>, covering a wide range of the <i>Ascomycota</i> clade. We have determined theAntioxidants (Basel, Switzerland)1810https://www.ebi.ac.uk/biostudies/studies/S-EPMC10604656biostudies-literatureComparing Mitochondrial Activity, Oxidative Stress Tolerance, and Longevity of Thirteen <i>Ascomycota</i> Yeast Species.PMC10604656Martinez-Albo IAlba MMVega MAyte JHidalgo EGroger AfalseComparing Mitochondrial Activity, Oxidative Stress Tolerance, and Longevity of Thirteen <i>Ascomycota</i> Yeast Species.Aging is characterized by a number of hallmarks including loss of mitochondrial homeostasis and decay in stress tolerance, among others. Unicellular eukaryotes have been widely used to study chronological aging. As a general trait, calorie restriction and activation of mitochondrial respiration has been proposed to contribute to an elongated lifespan. Most aging-related studies have been conducted with the Crabtree-positive yeasts <i>Saccharomyces cerevisiae</i> and <i>Schizosaccharomyces pombe</i>, and with deletion collections deriving from these conventional yeast models. We have performed an unbiased characterization of longevity using thirteen fungi species, including <i>S. cerevisiae</i> and <i>S. pombe</i>, covering a wide range of the <i>Ascomycota</i> clade. We have determined the2023-01-01T00:00:00Z2023 Sep2025-04-25T17:36:01.694Z2025-04-06T05:03:01.655ZS-EPMC106046563789188910.3390/antiox12101810