biostudies-literatureLovett RNIA NIH HHSe077911https://www.ebi.ac.uk/biostudies/studies/S-EPMC10618985biostudies-literatureUnknown13(10)<h4>Introduction</h4>COVID-19 is an unprecedented public health threat in modern times, especially for older adults or those with chronic illness. Beyond the threat of infection, the pandemic may also have longer-term impacts on mental and physical health. The COVID-19 & Chronic Conditions ('C3') study offers a unique opportunity to assess psychosocial and health/healthcare trajectories over 5 years among a diverse cohort of adults with comorbidities well-characterised from before the pandemic, at its onset, through multiple surges, vaccine rollouts and through the gradual easing of restrictions as society slowly returns to 'normal'.<h4>Methods and analysis</h4>The C3 study is an extension of an ongoing longitudinal cohort study of 'high-risk' adults (aged 23-88 at baseline) with one or moBMJ openLong-term impact of the COVID-19 pandemic on self-management of chronic conditions among high-risk adults in the USA: protocol for the C3 observational cohort study.PMC10618985R01 AG075043K01 AG070107Lowe SWismer GWeiner-Light SRussell ACurtis LMMorrissey Kwasny MO'Conor RYoshino Benavente JLovett RZheng PBailey SCYoon EVogeley AFilec SWolf MFederman ABonham MfalseLong-term impact of the COVID-19 pandemic on self-management of chronic conditions among high-risk adults in the USA: protocol for the C3 observational cohort study.<h4>Introduction</h4>COVID-19 is an unprecedented public health threat in modern times, especially for older adults or those with chronic illness. Beyond the threat of infection, the pandemic may also have longer-term impacts on mental and physical health. The COVID-19 & Chronic Conditions ('C3') study offers a unique opportunity to assess psychosocial and health/healthcare trajectories over 5 years among a diverse cohort of adults with comorbidities well-characterised from before the pandemic, at its onset, through multiple surges, vaccine rollouts and through the gradual easing of restrictions as society slowly returns to 'normal'.<h4>Methods and analysis</h4>The C3 study is an extension of an ongoing longitudinal cohort study of 'high-risk' adults (aged 23-88 at baseline) with one or mo2023-01-01T00:00:00Z2023 Oct2025-04-22T13:41:38.331Z2025-04-06T00:46:12.181ZS-EPMC106189853789916410.1136/bmjopen-2023-077911