biostudies-literatureUnknown14Zhang ZHuman skin microbes play critical roles in skin health and diseases. Microbes colonizing on the skin of Tibetans living in the high-altitude area for generations may have a stronger ability to resist the harsh environment, such as high ultraviolet radiation (UV). Isolation of a potential probiotic from Tibetans skin is beneficial for resistance of skin disease for humans in the world. In this study, the signature microbiota for Tibetan skin were characterized compared to low-altitude humans. Next, using culture-omics, 118 species were isolated. The culturability of high-altitude of Tibetan skin microbiome reached approximate 66.8%. Next, we found that one strain, <i>Pantoea eucrina</i>, had the greatest ability to repair UV damage to the skin as the lowest pathological score was observed iFrontiers in microbiology1273902https://www.ebi.ac.uk/biostudies/studies/S-EPMC10620709biostudies-literatureScreening and evaluation of skin potential probiotic from high-altitude Tibetans to repair ultraviolet radiation damage.PMC10620709Hua YZeng BLi YZhang ZRan HDeng FChai JfalseScreening and evaluation of skin potential probiotic from high-altitude Tibetans to repair ultraviolet radiation damage.Human skin microbes play critical roles in skin health and diseases. Microbes colonizing on the skin of Tibetans living in the high-altitude area for generations may have a stronger ability to resist the harsh environment, such as high ultraviolet radiation (UV). Isolation of a potential probiotic from Tibetans skin is beneficial for resistance of skin disease for humans in the world. In this study, the signature microbiota for Tibetan skin were characterized compared to low-altitude humans. Next, using culture-omics, 118 species were isolated. The culturability of high-altitude of Tibetan skin microbiome reached approximate 66.8%. Next, we found that one strain, <i>Pantoea eucrina</i>, had the greatest ability to repair UV damage to the skin as the lowest pathological score was observed i2023-01-01T00:00:00Z20232026-05-28T20:29:50.922Z2025-04-06T02:22:37.497ZS-EPMC106207093792868810.3389/fmicb.2023.1273902