{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jin J"],"funding":["Hangzhou Science and Technology Plan Development Project","National Key R&D Program of China","CAMS Innovation Fund for Medical Sciences","Medical and Health Science and Technology Project of Hangzhou","National Natural Science Foundation of China","National Key Research and Development Program of China"],"pagination":["e13493"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10623940"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["56(11)"],"pubmed_abstract":["Cell migration and proliferation are conducive to wound healing; however, regulating cell proliferation remains challenging, and excessive proliferation is an important cause of scar hyperplasia. Here, we aimed to explore how a subvacuum environment promotes wound epithelisation without affecting scar hyperplasia. Human immortalized keratinocyte cells and human skin fibroblasts were cultured under subvacuum conditions (1/10 atmospheric pressure), and changes in cell proliferation and migration, target protein content, calcium influx, and cytoskeleton and membrane fluidity were observed. Mechanical calcium (Ca<sup>2+</sup> ) channel blockers were used to prevent Ca<sup>2+</sup> influx for reverse validation. A rat wound model was used to elucidate the mechanism of the subvacuum dressing in "],"journal":["Cell proliferation"],"pubmed_title":["Subvacuum environment-enhanced cell migration promotes wound healing without increasing hypertrophic scars caused by excessive cell proliferation."],"pmcid":["PMC10623940"],"funding_grant_id":["2019YFA0110603","2019YFA0110602","2019YFA0110601","2019YFA0110600","B20200432","81772125","2019-I2M-5-076","81930057","81772076","20210133X01"],"pubmed_authors":["Fang H","Xia ZF","Pan BH","Zhu SH","Sun Y","Wu GS","Liu Y","Wang KA","Chen Y","Zhu LL","Zhu BH","Jin J","Yu SS"],"additional_accession":[]},"is_claimable":false,"name":"Subvacuum environment-enhanced cell migration promotes wound healing without increasing hypertrophic scars caused by excessive cell proliferation.","description":"Cell migration and proliferation are conducive to wound healing; however, regulating cell proliferation remains challenging, and excessive proliferation is an important cause of scar hyperplasia. Here, we aimed to explore how a subvacuum environment promotes wound epithelisation without affecting scar hyperplasia. Human immortalized keratinocyte cells and human skin fibroblasts were cultured under subvacuum conditions (1/10 atmospheric pressure), and changes in cell proliferation and migration, target protein content, calcium influx, and cytoskeleton and membrane fluidity were observed. Mechanical calcium (Ca<sup>2+</sup> ) channel blockers were used to prevent Ca<sup>2+</sup> influx for reverse validation. A rat wound model was used to elucidate the mechanism of the subvacuum dressing in ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-04-21T23:54:07.614Z","creation":"2025-04-05T19:19:41.005Z"},"accession":"S-EPMC10623940","cross_references":{"pubmed":["37128180"],"doi":["10.1111/cpr.13493"]}}