biostudies-literatureJoint Head and Neck Radiotherapy-MRI Development CooperativeNIDCR NIH HHSNIBIB NIH HHSNCATS NIH HHSNCI NIH HHS065501https://www.ebi.ac.uk/biostudies/studies/S-EPMC10627232biostudies-literatureUnknown10(6)<h4>Purpose</h4>To improve segmentation accuracy in head and neck cancer (HNC) radiotherapy treatment planning for the 1.5T hybrid magnetic resonance imaging/linear accelerator (MR-Linac), three-dimensional (3D), T2-weighted, fat-suppressed magnetic resonance imaging sequences were developed and optimized.<h4>Approach</h4>After initial testing, spectral attenuated inversion recovery (SPAIR) was chosen as the fat suppression technique. Five candidate SPAIR sequences and a nonsuppressed, T2-weighted sequence were acquired for five HNC patients using a 1.5T MR-Linac. MR physicists identified persistent artifacts in two of the SPAIR sequences, so the remaining three SPAIR sequences were further analyzed. The gross primary tumor volume, metastatic lymph nodes, parotid glands, and pterygoid muscJournal of medical imaging (Bellingham, Wash.)Development and implementation of optimized endogenous contrast sequences for delineation in adaptive radiotherapy on a 1.5T MR-linear-accelerator: a prospective R-IDEAL stage 0-2a quantitative/qualitative evaluation of <i>in vivo</i> site-specific quality-assurance using a 3D T2 fat-suppressed platform for head and neck cancer.PMC10627232R01 CA218148F31 DE029093T32 CA261856P30 CA016672TL1 TR003169R01 DE025248R01 DE028290R25 EB025787F31 DE031502McDonald BADresner MAMohamed ASRAhmed SWay ACorrigan KLAndring LJoint Head and Neck Radiotherapy-MRI Development CooperativePinnix CFuller CDSalzillo TCWahid KAHe RWang JMulder SDing YManzar GSYoder AStafford RJChristodouleas JNaser MAfalseDevelopment and implementation of optimized endogenous contrast sequences for delineation in adaptive radiotherapy on a 1.5T MR-linear-accelerator: a prospective R-IDEAL stage 0-2a quantitative/qualitative evaluation of <i>in vivo</i> site-specific quality-assurance using a 3D T2 fat-suppressed platform for head and neck cancer.<h4>Purpose</h4>To improve segmentation accuracy in head and neck cancer (HNC) radiotherapy treatment planning for the 1.5T hybrid magnetic resonance imaging/linear accelerator (MR-Linac), three-dimensional (3D), T2-weighted, fat-suppressed magnetic resonance imaging sequences were developed and optimized.<h4>Approach</h4>After initial testing, spectral attenuated inversion recovery (SPAIR) was chosen as the fat suppression technique. Five candidate SPAIR sequences and a nonsuppressed, T2-weighted sequence were acquired for five HNC patients using a 1.5T MR-Linac. MR physicists identified persistent artifacts in two of the SPAIR sequences, so the remaining three SPAIR sequences were further analyzed. The gross primary tumor volume, metastatic lymph nodes, parotid glands, and pterygoid musc2023-01-01T00:00:00Z2023 Nov2026-06-01T20:32:04.178Z2025-04-04T11:43:13.849ZS-EPMC106272323793725910.1117/1.JMI.10.6.065501