{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu Z"],"funding":["NIAID NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases","NCI NIH HHS","NIH HHS"],"pagination":["6943"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10628232"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Chromatin conformation reorganization is emerging as an important layer of regulation for gene expression and lineage specification. Yet, how lineage-specific transcription factors contribute to the establishment of cell type-specific 3D chromatin architecture in the immune cells remains unclear, especially for the late stages of T cell subset differentiation and maturation. Regulatory T cells (Treg) are mainly generated in the thymus as a subpopulation of T cells specializing in suppressing excessive immune responses. Here, by comprehensively mapping 3D chromatin organization during Treg cell differentiation, we show that Treg-specific chromatin structures were progressively established during its lineage specification, and highly associated with Treg signature gene expression. Additional"],"journal":["Nature communications"],"pubmed_title":["Foxp3 orchestrates reorganization of chromatin architecture to establish regulatory T cell identity."],"pmcid":["PMC10628232"],"funding_grant_id":["R01 AI107027","R01-AI107027","R21 AI178938","P30 CA014195","DP5 OD023071","R21 AI154919","R21-AI178938","U01 CA260700","R01 AI151123","S10 OD023689"],"pubmed_authors":["Liu Z","Zheng Y","Dixon JR","Liang Y","Lee DS"],"additional_accession":[]},"is_claimable":false,"name":"Foxp3 orchestrates reorganization of chromatin architecture to establish regulatory T cell identity.","description":"Chromatin conformation reorganization is emerging as an important layer of regulation for gene expression and lineage specification. Yet, how lineage-specific transcription factors contribute to the establishment of cell type-specific 3D chromatin architecture in the immune cells remains unclear, especially for the late stages of T cell subset differentiation and maturation. Regulatory T cells (Treg) are mainly generated in the thymus as a subpopulation of T cells specializing in suppressing excessive immune responses. Here, by comprehensively mapping 3D chromatin organization during Treg cell differentiation, we show that Treg-specific chromatin structures were progressively established during its lineage specification, and highly associated with Treg signature gene expression. Additional","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2026-07-14T22:40:45.493Z","creation":"2025-02-18T23:31:00.869Z"},"accession":"S-EPMC10628232","cross_references":{"pubmed":["37932264"],"doi":["10.1038/s41467-023-42647-y"]}}