{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Ji F"],"pubmed_abstract":["Antimicrobial peptides represent a promising therapeutic alternative for the treatment of antibiotic-resistant bacterial infections. 2K4L is a rationally-designed analog of a short peptide temporin-1CEc, a natural peptide isolated and purified from the skin secretions of the Chinese brown frog <i>Rana chensinensis</i> by substituting amino acid residues. 2K4L adopt an α-helical confirm in a membrane-mimetic environment and displayed an improved and broad-spectrum antibacterial activity against sensitive and multidrug-resistant Gram-negative and Gram-positive bacterial strains. Here, the action mechanism of 2K4L on multidrug resistant <i>Acinetobacter baumannii</i> (MRAB) and protection on MRAB-infected mice was investigated. The results demonstrated high bactericidal activity of 2K4L again"],"journal":["Frontiers in microbiology"],"pagination":["1258469"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10628664"],"repository":["biostudies-literature"],"pubmed_title":["Antimicrobial peptide 2K4L disrupts the membrane of multidrug-resistant <i>Acinetobacter baumannii</i> and protects mice against sepsis."],"pmcid":["PMC10628664"],"pubmed_authors":["Tian G","Jiang F","Ji F","Shang D"],"additional_accession":[]},"is_claimable":false,"name":"Antimicrobial peptide 2K4L disrupts the membrane of multidrug-resistant <i>Acinetobacter baumannii</i> and protects mice against sepsis.","description":"Antimicrobial peptides represent a promising therapeutic alternative for the treatment of antibiotic-resistant bacterial infections. 2K4L is a rationally-designed analog of a short peptide temporin-1CEc, a natural peptide isolated and purified from the skin secretions of the Chinese brown frog <i>Rana chensinensis</i> by substituting amino acid residues. 2K4L adopt an α-helical confirm in a membrane-mimetic environment and displayed an improved and broad-spectrum antibacterial activity against sensitive and multidrug-resistant Gram-negative and Gram-positive bacterial strains. Here, the action mechanism of 2K4L on multidrug resistant <i>Acinetobacter baumannii</i> (MRAB) and protection on MRAB-infected mice was investigated. The results demonstrated high bactericidal activity of 2K4L again","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-04-08T13:52:54.759Z","creation":"2025-02-19T00:01:35.552Z"},"accession":"S-EPMC10628664","cross_references":{"pubmed":["37942076"],"doi":["10.3389/fmicb.2023.1258469"]}}