biostudies-literatureUnknown88(21)Iii RCOffice of Research and Economic Development, University of California, RiversideManipulating carbon-centered radicals to add to electron-deficient systems is a well-precedented process. By coupling the Fe(II)-mediated Fenton reaction with the Fe(III)-mediated single-electron oxidation of anisolic compounds, we demonstrate how electron-rich carbon-centered radicals can react with electron-rich arenes through a radical-polar cascade pathway. This bioinspired approach produces diarylmethane derivatives from simple unfunctionalized precursors.The Journal of organic chemistry15060-15066https://www.ebi.ac.uk/biostudies/studies/S-EPMC10629232biostudies-literatureA Fenton Approach to Aromatic Radical Cations and Diarylmethane Synthesis.PMC10629232Iii RCLujan BDeBow JDManasi RMartinez AKou KGMfalseA Fenton Approach to Aromatic Radical Cations and Diarylmethane Synthesis.Manipulating carbon-centered radicals to add to electron-deficient systems is a well-precedented process. By coupling the Fe(II)-mediated Fenton reaction with the Fe(III)-mediated single-electron oxidation of anisolic compounds, we demonstrate how electron-rich carbon-centered radicals can react with electron-rich arenes through a radical-polar cascade pathway. This bioinspired approach produces diarylmethane derivatives from simple unfunctionalized precursors.2023-01-01T00:00:00Z2023 Nov2025-04-05T10:23:12.533Z2025-04-05T10:23:12.533ZS-EPMC106292323784705010.1021/acs.joc.3c01505