{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li M"],"funding":["Tianjin Commission of Science and Technology","Frontiers Science Center for New Organic Matter","MOST | National Natural Science Foundation of China"],"pagination":["e2305705120"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10629531"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["120(29)"],"pubmed_abstract":["The assimilation of antibiotic resistance genes (ARGs) by pathogenic bacteria poses a severe threat to public health. Here, we reported a dual-reaction-site-modified Co<sub>SA</sub>/Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> (single cobalt atoms immobilized on Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene) for effectively deactivating extracellular ARGs via peroxymonosulfate (PMS) activation. The enhanced removal of ARGs was attributed to the synergistic effect of adsorption (Ti sites) and degradation (Co-O<sub>3</sub> sites). The Ti sites on Co<sub>SA</sub>/Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> nanosheets bound with PO<sub>4</sub><sup>3-</sup> on the phosphate skeletons of ARGs via Ti-O-P coordination interactions, achieving excellent adsorption capacity (10.21 × 10<sup>10</sup> copies mg<sup>-1</sup>) for <i>tetA,</i> and the Co-O<sub>3</sub> sites activated PMS into surface-bond hydroxyl radicals (•OH<sub>surface</sub>), which can quickly attack the backbones and bases of the adsorbed ARGs, resulting in the efficient in situ degradation of ARGs into inactive small molecular organics and NO<sub>3</sub>. This dual-reaction-site Fenton-like system exhibited ultrahigh extracellular ARG degradation rate (k > 0.9 min<sup>-1</sup>) and showed the potential for practical wastewater treatment in a membrane filtration process, which provided insights for extracellular ARG removal via catalysts design."],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Single cobalt atoms anchored on Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> with dual reaction sites for efficient adsorption-degradation of antibiotic resistance genes."],"pmcid":["PMC10629531"],"funding_grant_id":["22225604 22076082","20YFZCSN01070","21874099 22176140","63181206","22006029 42277059","21YFSNSN00250"],"pubmed_authors":["Li Y","Wang P","Zhang K","Zhan S","Bao Y","Zhang H","Crittenden JC","Li M"],"additional_accession":[]},"is_claimable":false,"name":"Single cobalt atoms anchored on Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> with dual reaction sites for efficient adsorption-degradation of antibiotic resistance genes.","description":"The assimilation of antibiotic resistance genes (ARGs) by pathogenic bacteria poses a severe threat to public health. Here, we reported a dual-reaction-site-modified Co<sub>SA</sub>/Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> (single cobalt atoms immobilized on Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene) for effectively deactivating extracellular ARGs via peroxymonosulfate (PMS) activation. The enhanced removal of ARGs was attributed to the synergistic effect of adsorption (Ti sites) and degradation (Co-O<sub>3</sub> sites). The Ti sites on Co<sub>SA</sub>/Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> nanosheets bound with PO<sub>4</sub><sup>3-</sup> on the phosphate skeletons of ARGs via Ti-O-P coordination interactions, achieving excellent adsorption capacity (10.21 × 10<sup>10</sup> copies mg<sup>-1</sup>) for <i>tetA,</i> and the Co-O<sub>3</sub> sites activated PMS into surface-bond hydroxyl radicals (•OH<sub>surface</sub>), which can quickly attack the backbones and bases of the adsorbed ARGs, resulting in the efficient in situ degradation of ARGs into inactive small molecular organics and NO<sub>3</sub>. This dual-reaction-site Fenton-like system exhibited ultrahigh extracellular ARG degradation rate (k > 0.9 min<sup>-1</sup>) and showed the potential for practical wastewater treatment in a membrane filtration process, which provided insights for extracellular ARG removal via catalysts design.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jul","modification":"2025-04-05T10:45:38.99Z","creation":"2025-04-05T10:45:38.99Z"},"accession":"S-EPMC10629531","cross_references":{"pubmed":["37428922"],"doi":["10.1073/pnas.2305705120"]}}