{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wengler K"],"funding":["NIMH NIH HHS"],"pagination":["198-208"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10633403"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["81(2)"],"pubmed_abstract":["<h4>Importance</h4>The link between psychosis and dopaminergic dysfunction is established, but no generalizable biomarkers with clear potential for clinical adoption exist.<h4>Objective</h4>To replicate previous findings relating neuromelanin-sensitive magnetic resonance imaging (NM-MRI), a proxy measure of dopamine function, to psychosis severity in antipsychotic-free individuals in the psychosis spectrum and to evaluate the out-of-sample predictive ability of NM-MRI for psychosis severity.<h4>Design, setting, and participants</h4>This cross-sectional study recruited participants from 2019 to 2023 in the New York City area (main samples) and Mexico City area (external validation sample). The main samples consisted of 42 antipsychotic-free patients with schizophrenia, 53 antipsychotic-free"],"journal":["JAMA psychiatry"],"pubmed_title":["Generalizability and Out-of-Sample Predictive Ability of Associations Between Neuromelanin-Sensitive Magnetic Resonance Imaging and Psychosis in Antipsychotic-Free Individuals."],"pmcid":["PMC10633403"],"funding_grant_id":["R01 MH114965","R01 MH110270","F32 MH125540","R01 MH117323"],"pubmed_authors":["Velikovskaya A","Lee S","Baker SC","Girgis RR","Ojeil N","Wengler K","de la Fuente-Sandoval C","Fogelson A","Reyes-Madrigal F","Horga G"],"additional_accession":[]},"is_claimable":false,"name":"Generalizability and Out-of-Sample Predictive Ability of Associations Between Neuromelanin-Sensitive Magnetic Resonance Imaging and Psychosis in Antipsychotic-Free Individuals.","description":"<h4>Importance</h4>The link between psychosis and dopaminergic dysfunction is established, but no generalizable biomarkers with clear potential for clinical adoption exist.<h4>Objective</h4>To replicate previous findings relating neuromelanin-sensitive magnetic resonance imaging (NM-MRI), a proxy measure of dopamine function, to psychosis severity in antipsychotic-free individuals in the psychosis spectrum and to evaluate the out-of-sample predictive ability of NM-MRI for psychosis severity.<h4>Design, setting, and participants</h4>This cross-sectional study recruited participants from 2019 to 2023 in the New York City area (main samples) and Mexico City area (external validation sample). The main samples consisted of 42 antipsychotic-free patients with schizophrenia, 53 antipsychotic-free","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-07-16T13:21:23.333Z","creation":"2026-07-09T10:56:36.349Z"},"accession":"S-EPMC10633403","cross_references":{"pubmed":["37938847"],"doi":["10.1001/jamapsychiatry.2023.4305"]}}