biostudies-literatureZhang HPeking University Third Hospital1361-1371https://www.ebi.ac.uk/biostudies/studies/S-EPMC10635907biostudies-literatureUnknown96(10)<h4>Background and purpose</h4>Efforts to improve nurses' physical and mental health are critical to ensuring the safety and quality of the healthcare system. Long-term studies targeting the relevancy of nurses' occupation characteristics with health conditions remain insufficient. This study aimed to examine the relationship between nurses' night shift and sleep problems and metabolic abnormalities risk.<h4>Methods</h4>This study was a part of the National Nurse Health Study, an ambispective cohort study in China, in 2021. Based on an integration physical examination data system, this study carried out a retrospective analysis of 730 nurses from 2018 to 2020 and combined with a questionnaire survey in 2021. The STROBE guidelines were adopted for reporting.<h4>Results</h4>In the 23 (23.0, International archives of occupational and environmental healthRelationship between night shift and sleep problems, risk of metabolic abnormalities of nurses: a 2 years follow-up retrospective analysis in the National Nurse Health Study (NNHS).PMC10635907BYSYDL2019012Zhuo LTong SWang PGeng RHu JZhan SZhang HChe YLi BZhang SZhou YWang JfalseRelationship between night shift and sleep problems, risk of metabolic abnormalities of nurses: a 2 years follow-up retrospective analysis in the National Nurse Health Study (NNHS).<h4>Background and purpose</h4>Efforts to improve nurses' physical and mental health are critical to ensuring the safety and quality of the healthcare system. Long-term studies targeting the relevancy of nurses' occupation characteristics with health conditions remain insufficient. This study aimed to examine the relationship between nurses' night shift and sleep problems and metabolic abnormalities risk.<h4>Methods</h4>This study was a part of the National Nurse Health Study, an ambispective cohort study in China, in 2021. Based on an integration physical examination data system, this study carried out a retrospective analysis of 730 nurses from 2018 to 2020 and combined with a questionnaire survey in 2021. The STROBE guidelines were adopted for reporting.<h4>Results</h4>In the 23 (23.0, 2023-01-01T00:00:00Z2023 Dec2025-05-18T10:57:26.778Z2025-05-18T10:57:26.778ZS-EPMC106359073787440310.1007/s00420-023-02014-2