biostudies-literatureUnknown18(8)Triggianese PUniversità degli Studi di SienaTo characterize clinical and laboratory signs of patients with Still's disease experiencing macrophage activation syndrome (MAS) and identify factors associated with MAS development. Patients with Still's disease classified according to internationally accepted criteria were enrolled in the AutoInflammatory Disease Alliance (AIDA) Still's Disease Registry. Clinical and laboratory features observed during the inflammatory attack complicated by MAS were included in univariate and multivariate logistic regression analysis to identify factors associated to MAS development. A total of 414 patients with Still's disease were included; 39 (9.4%) of them developed MAS during clinical history. At univariate analyses, the following variables were significantly associated with MAS: classification of aInternal and emergency medicine2231-2243https://www.ebi.ac.uk/biostudies/studies/S-EPMC10635948biostudies-literatureClinical and laboratory features associated with macrophage activation syndrome in Still's disease: data from the international AIDA Network Still's Disease Registry.PMC10635948Ruscitti PKourtesi KDagna LFrassi MFrediani BTufan AGidaro ACarubbi FTharwat SLa Torre FAl-Maghlouth IGovoni MGiacomelli RRagab GChimenti MSKardas RCSevik GSota JGaggiano COgunjimi BSfikakis PPSimonini GIagnocco ASaad MASpedicato VSfriso PConforti ACaggiano VDi Cola IMonti SDel Giudice EFabiani CCipriani PLo Gullo ABalistreri ABindoli STombetti ELaskari KNavarini LWiesik-Szewczyk EErten SHinojosa-Azaola ACartocci AAsfina KNConti GSebastiani GDIannone FRubegni GVitale ACiccia FCampochiaro COlivieri ANKaramanakos ADagostin MAde Brito Antonelli IPAlibaz-Oner FGentileschi SCantarini LNuzzolese RBartoloni EAli HHTriggianese PDireskeneli HFotis LHernandez-Rodriguez JMartin-Nares EMarino ALopalco GIacono DMakowska JDe Paulis AMaggio MCEmmi GPatrone MMayrink Giardini HAViapiana OTorres-Ruiz JMaier ATarsia MfalseClinical and laboratory features associated with macrophage activation syndrome in Still's disease: data from the international AIDA Network Still's Disease Registry.To characterize clinical and laboratory signs of patients with Still's disease experiencing macrophage activation syndrome (MAS) and identify factors associated with MAS development. Patients with Still's disease classified according to internationally accepted criteria were enrolled in the AutoInflammatory Disease Alliance (AIDA) Still's Disease Registry. Clinical and laboratory features observed during the inflammatory attack complicated by MAS were included in univariate and multivariate logistic regression analysis to identify factors associated to MAS development. A total of 414 patients with Still's disease were included; 39 (9.4%) of them developed MAS during clinical history. At univariate analyses, the following variables were significantly associated with MAS: classification of a2023-01-01T00:00:00Z2023 Nov2026-06-03T15:05:39.465Z2025-04-20T10:07:31.434ZS-EPMC106359483782826810.1007/s11739-023-03408-3